Experimental Denture Pastes

A Randomized Trial of Experimental Dentifrices for Cleaning Dentures

This trial aims to evaluate the efficacy of three experimental dentifrices to remove denture biofilm. Complete denture wearers will be instructed to brush their dentures with a specific toothbrush and four compositions: (1) A proprietary denture-specific paste (active comparator); (2) 0.2% chloramine T; (3) 1.0% chloramine T; (4) 0.01% fluorosurfactant. Each treatment will be used for periods of 7 days, and participants will be randomized to use them according to one of four sequences.

Inclusion Criteria:

• Completely edentulous
• Good general health
• Patients requesting new complete dentures (volunteers will receive the interventions before new complete dentures)
• Regular wearing of the same maxillary and mandibular complete dentures for 3 to 10 years
• Both denture bases and artificial teeth should be composed by acrylic resin

Exclusion Criteria:

• Unsatisfactory complete dentures in use (i.e. with poor fitting, relining or fractures)
• Absence of deposits of biofilm at baseline