This trial aims to evaluate the efficacy of three experimental dentifrices to remove denture biofilm. Complete denture wearers will be instructed to brush their dentures with a specific toothbrush and four compositions: (1) A proprietary denture-specific paste (active comparator); (2) 0.2% chloramine T; (3) 1.0% chloramine T; (4) 0.01% fluorosurfactant. Each treatment will be used for periods of 7 days, and participants will be randomized to use them according to one of four sequences.

Inclusion Criteria:

• Completely edentulous
• Good general health
• Patients requesting new complete dentures (volunteers will receive the interventions before new complete dentures)
• Regular wearing of the same maxillary and mandibular complete dentures for 3 to 10 years
• Both denture bases and artificial teeth should be composed by acrylic resin

Exclusion Criteria:

• Unsatisfactory complete dentures in use (i.e. with poor fitting, relining or fractures)
• Absence of deposits of biofilm at baseline