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| ID | Type | Description | Link |
|---|---|---|---|
| 1U19AI084024-01 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute of Allergy and Infectious Diseases (NIAID) | NIH |
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The goal of this project is to identify the microorganisms present in the endometrial samples obtained from women with or without evidence of endometritis using a combination of culture methods, rRNA sequencing and whole genomic sequencing. The overarching aim of these studies is to identify the etiology of endometritis. The investigators will define the role of fastidious anaerobic microorganisms in the etiology of PID, and assess whether antibiotic treatment regimens used for the treatment of PID have activity against the novel organisms linked with pelvic infections.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Endometrial biospy samples | The Endometrial Biopsy samples will be provided by women enrolled in the University of Pittsburgh IRB PRO10010112 and PRO10010159 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| no intervention | Other | Not Applicable- no intervention |
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| Measure | Description | Time Frame |
|---|---|---|
| Identification of Novel Organsims from PRO10010159 | This study will use optimized culture methods which can support the growth of fastidious organisms to describe the microorganisms in endometrial tissue samples obtained from the 200 women enrolled in the cervicitis cohort (PRO10010159, T Cell Response). | 12 months after participant enrollment in PRO10010159 |
| Identification of Novel Organisms from PRO10010112 | This study will use optimized culture methods which can support the growth of fastidious organisms to describe the microorganisms in endometrial tissue samples obtained from 250 women enrolled in the acute PID study before and after treatment (PRO10010112, Acute PID treatment). | 30 days after participant enrollment in PRO10010112 |
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Inclusion Criteria:
Exclusion Criteria:
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Endometrial biopsy samples from women participating in University of Pittsburgh IRB PRO10010112 and PRO10010159
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| Name | Affiliation | Role |
|---|---|---|
| Sharon L Hillier, PhD | University of Pittsburgh | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Magee-Womens Research Institute | Pittsburgh | Pennsylvania | 15213 | United States |
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| ID | Term |
|---|---|
| D000292 | Pelvic Inflammatory Disease |
| ID | Term |
|---|---|
| D034161 | Pelvic Infection |
| D007239 | Infections |
| D000291 | Adnexal Diseases |
| D005831 | Genital Diseases, Female |
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Endometrial biopsy specimens and isolates may be retained and stored in various registries such as:
| D052776 |
| Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D000091662 | Genital Diseases |