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| Name | Class |
|---|---|
| Harvard University | OTHER |
| University Hospital, Essen | OTHER |
| Auckland City Hospital | OTHER_GOV |
| University Hospital, Strasbourg, France |
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The purpose of this multicenter study is to evaluate the agreement among expert radiologists in interpreting magnetic resonance images (MRI) assessing common primary liver tumours in non-cirrhotic patients.
Magnetic Resonance Imaging (MRI) is currently the method of choice for non-invasive diagnosis of primary liver tumors. However, differentiation of hepatocellular carcinoma (HCC) from adenoma and focal nodular hyperplasia (FNH) remains challenging, particularly in non-cirrhotic patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Primary liver tumors, non-cirrhotic | This single Cohort/Group will include all consecutive patients that received pre-operative Magnetic Resonance Imaging (MRI) and underwent resection for primary liver tumors. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Non-invasive Magnetic Resonance Imaging (MRI) | Other | Conventional pre-operative MRI |
|
| Measure | Description | Time Frame |
|---|---|---|
| Inter-observer agreement among expert radiologists in diagnosing primary liver tumors by Magnetic Resonance Imaging (MRI). | Inter-observer agreement for categorical data will by assessed by the Fliess' kappa (good agreement >0.7). | December 2010 |
| Measure | Description | Time Frame |
|---|---|---|
| Agreement of radiologists with the actual diagnosis of primary liver tumors assessed by Magnetic Resonance Imaging (MRI). | The actual diagnosis is defined as the histopathology diagnosis of the resected liver specimen, the current gold standard technique. Such agreement will be assessed by Cohen's Kappa (good agreement >0.7). | December 2010 |
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Inclusion Criteria:
Exclusion Criteria:
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Primary care clinics
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| Name | Affiliation | Role |
|---|---|---|
| Stefan Breitenstein, MD | University Hospital Zurich, Department of Visceral and Transplant Surgery, Zurich, Switzerland | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Harvard Medical School, Massachusetts General Hospital, and Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02117-0825 | United States |
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| Label | URL |
|---|---|
| Inter-rater reliability (also called: inter-rater agreement, or concordance) definitions and further information | View source |
| Fleiss' kappa information | View source |
| Cohen's kappa information |
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| OTHER |
| The Leeds Teaching Hospitals NHS Trust | OTHER |
| Imperial College London | OTHER |
| University College London Hospitals | OTHER |
| St. Louis University | OTHER |
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| Liver resection | Procedure | Hepatectomy with an intention to cure |
|
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| Histopathology diagnosis of resected liver specimen | Other | Histopathology diagnosis by expert pathologist. |
|
|
| Differences in radiologist' certainty of diagnosis (CoD) among different tumor types. | Radiologist' certainty of diagnosis (CoD) will be assessed by a Visual Analogue Scale (VAS 1-10). Potential differences in CoD will be identified by non-parametric multiple comparisons. | December 2010 |
| Intra-class correlation coefficient among radiologists' Certainty of Diagnosis (CoD) in diagnosis primary liver tumors by Magnetic Resonant Imaging (MRI) | Intra-class correlation coefficient is a descriptive statistic that can be used when quantitative measurements are made on units that are organized into groups. It describes how strongly units in the same group resemble each other. | December 2010 |
| Investigate the diagnostic efficacy of radiologists' certainty of diagnosis (CoD) in accurately predicting primary liver tumors assessed by Magnetic Resonant Imaging (MRI) | Diagnostic efficacy will be assessed by Receiver Operating Characteristic (ROC) Curves. | December 2010 |
| St. Louis University, Liver Center | St Louis | Missouri | 63110-0250 | United States |
| University Hospital Strasbourg | Strasbourg | Cedex | 67098 | France |
| University Hospital Essen | Essen | 45147 | Germany |
| Auckland City Hospital | Auckland | Auckland | 9 | New Zealand |
| University Hospital Zurich, Department of Interventional and Diagnostic Radiology | Zurich | Canton of Zurich | 8091 | Switzerland |
| University Hospital Zurich, Department of Visceral and Transplant Surgery, Swiss Hepato-Pancreato-Biliary (HPB) Center | Zurich | Canton of Zurich | 8091 | Switzerland |
| The Leeds Teaching Hospitals NHS Trust | Leeds | LS9 7TF | United Kingdom |
| University College London Hospitals NHS Foundation Trust | London | NW1 2PG | United Kingdom |
| Imperial College, Hammersmith Hospital | London | W12 0HS | United Kingdom |
| View source |
| Intraclass correlation information | View source |
| ID | Term |
|---|---|
| D009369 | Neoplasms |
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| ID | Term |
|---|---|
| D009682 | Magnetic Resonance Spectroscopy |
| D006498 | Hepatectomy |
| ID | Term |
|---|---|
| D013057 | Spectrum Analysis |
| D002623 | Chemistry Techniques, Analytical |
| D008919 | Investigative Techniques |
| D013505 | Digestive System Surgical Procedures |
| D013514 | Surgical Procedures, Operative |
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