Antibiotic Treatment of Recurrent Episodes of Asthma in Children

Antibiotic Treatment of Recurrent Episode of Asthma in Children - a Randomised, Case-controlled Study Within the COPSAC2010 Cohort (Asthma Begins in Childhood)

Copsac has discovered that asthmatic exacerbations are as closely linked to bacterial as to viral infection. The current study will examine whether treatment of asthmatic exacerbations with macrolide antibiotics - in the abscence of clear clinical bacterial infection which would in any case precipitate antibiotic treatment - has an effect on either the particular episode, or subsequently. Macrolide antibiotics are chosen for ease of administration ensuring high compliance, antibiotic appropriacy, and anti-inflammatory properties.

Inclusion Criteria:

• Participation in the COPSAC2010 cohort
• recurrent wheeze
• and others

Exclusion Criteria:

• Macrolide allergy
• Heart, liver or kidney disease.
• and others