A Study of Brain Receptor Occupancy in Healthy Subjects

Assessment of Brain Kappa Opioid Receptor Occupancy After Single Oral Doses of LY2456302 as Measured by PET With Radioligand LY2879788 in Healthy Subjects

To measure the occupancy of brain kappa opioid receptors after single oral doses of LY2456302.

Inclusion Criteria:

• Healthy male or female
• Have clinical laboratory tests within normal reference ranges
• Have arterial and venous access sufficient to allow blood sampling

Exclusion Criteria:

• Currently enrolled in, or discontinued within the last 30 days from a clinical trial
• History of severe allergies or multiple adverse drug reactions
• Have an abnormal ECG at screening visit
• Have abnormal sitting blood pressure
• Have an increased risk of seizures
• Current suicidal ideation
• Positive test for HIV, hepatitis C, or hepatitis B
• Women who are breast feeding
• Smoke more than 10 cigarettes per day, or equivalent
• Drink more than 5 cups of coffee per day, or equivalent
• Have a history of head injury
• Unable to undergo a MRI
• Suffer from claustrophobia