To measure the occupancy of brain kappa opioid receptors after single oral doses of LY2456302.

Inclusion Criteria:

• Healthy male or female
• Have clinical laboratory tests within normal reference ranges
• Have arterial and venous access sufficient to allow blood sampling

Exclusion Criteria:

• Currently enrolled in, or discontinued within the last 30 days from a clinical trial
• History of severe allergies or multiple adverse drug reactions
• Have an abnormal ECG at screening visit
• Have abnormal sitting blood pressure
• Have an increased risk of seizures
• Current suicidal ideation
• Positive test for HIV, hepatitis C, or hepatitis B
• Women who are breast feeding
• Smoke more than 10 cigarettes per day, or equivalent
• Drink more than 5 cups of coffee per day, or equivalent
• Have a history of head injury
• Unable to undergo a MRI
• Suffer from claustrophobia