The purpose of this study is to determine the effectiveness of topical and oral antibiotics in eliminating carriage of methicillin-resistant Staphylococcus aureus (MRSA) among those living in the community. We hypothesize that a greater proportion of those who receive intervention will eliminate MRSA carriage compared to those who do not receive any intervention.

Inclusion Criteria:

• Prior MRSA infection (i.e index case)
• Identified as being colonized with MRSA on initial screen

Exclusion Criteria:

• Are pregnant or breastfeeding.
• Have indwelling catheters.
• Received prior decolonization treatment within last 6 months of enrollment.
• Have allergy to study medication.
• Are colonized with MRSA strain resistant to study medication.
• Have active infection requiring systemic antimicrobials.
• Are household contacts to index case.