Epidemiological studies showed that 20-30% of patients with uncomplicated urinary tract infections risked recurrent infection. Urinary tract infection causes marked discomfort for the patient, has a negative impact upon quality of life, and is associated with high social and health costs in terms of specialist appointments, laboratory and instrumental tests and prescriptions . Although diverse cycles of antibiotic therapy and prophylaxis have been proposed, doubts persist about the most efficacious pharmacological agents, duration of prophylaxis , the incidence of adverse effects and relapse when antibiotic therapy is suspended.

Aims of the study:

1. To compare the efficacy of two prophylactic schedules (Prulifloxacin vs Phosphomycin):

   • in reducing the number of urinary tract infection episodes during prophylaxis
   • in reducing the number of urinary tract infection episodes after prophylaxis
   • in improving the patient's quality of life .

2. To assess :

   • Tolerability of antibiotic prophylaxis
   • The incidence of resistance to antibiotic therapy

Inclusion Criteria:

• Female patients
• Age over 18 years old
• No allergies to the drugs to be prescribed
• No counter-indications to this drug therapy
• Urine culture shows responsiveness to drugs at recruitment of patient
• History of urinary tract infections with at least three episodes in the previous year or two in the past six months

Exclusion Criteria:

• Lack of tolerability of prescribed drugs