Safety and Efficacy of Brimonidine Tartrate/Timolol Fixed Combination in Patients With Glaucoma or Ocular Hypertension

This study will evaluate the safety and efficacy of brimonidine tartrate/timolol fixed combination (Combigan®) compared with brimonidine tartrate (Alphagan®) and timolol in patients with glaucoma or ocular hypertension who do not respond well to topical beta blockers.

Inclusion Criteria:

• Open-angle glaucoma or ocular hypertension in at least one eye that is not responsive to topical beta blockers
• No anticipated wearing of contact lenses during study

Exclusion Criteria:

• Active ocular disease other than glaucoma or ocular hypertension (eg, uveitis, ocular infections or severe dry eye)
• Any intraocular surgery or laser (eg, cataract surgery or Lasik) within 3 months
• Required regular use of other ocular medications except for occasional use of artificial tears