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| ID | Type | Description | Link |
|---|---|---|---|
| 2007-A00744-49 | Other Identifier | Afssaps | |
| DGS2007-0536 | Other Identifier | DGS |
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| Name | Class |
|---|---|
| Ministry of Health, France | OTHER_GOV |
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For a given food intake, fat and energy metabolism in adipose tissue and muscle adapt to nutrient intakes. This adaptation to nutrition may be impaired in susceptible individuals or in obese patients by promoting weight gain, either in constitutional thinness (MC) by blocking it. The MC is a little known entity. These patients wish to grow for her and others. Can they? We have demonstrated abnormalities of hormones regulating appetite (ghrelin, PYY, GLP1 and leptin) that may participate in thinness. Furthermore, this thinness is associated with osteoporosis in 25% of true MC who is 25 years old.
This project aims to overfed MCs and follow the control parameters of energy metabolism. We will look for abnormalities in the adaptation to overnutrition in subjects with genetic background of thinness, which could explain the resistance to weight gain. The answer could possibly help to understand obesity.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Constitutional thinness | Women with a a body mass index of less than 16.5 kg/m2 |
| |
| Healthy Volonteer | Women with a body mass index between 20 and 25 kg/m2 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lipid overnutrition | Behavioral | During 4 months, the daily caloric intake will be increased by about 70 g fat as butter 20 grams, 100 grams of cheese (Emmental) and 40 grams of almonds. This overnutrition corresponds to an excess of 760 kcal / day or 21,280 calories for the period and then taken to a theoretical 2.4 kg of fat (1 kg fat = 9000 kcal). |
| Measure | Description | Time Frame |
|---|---|---|
| gene expression | Level of genes (which regulate the lipid and energy metabolism) expression in fat and muscle tissues | After one month of lipid overnutrition |
| Measure | Description | Time Frame |
|---|---|---|
| Anthropometric parameter | Lean mass | After one month of lipid overnutrition |
| Autonomic nervous system activity | Heart rate variability analyses using ECG Holter monitoring |
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Inclusion Criteria:
Exclusion Criteria (common to the two groups):
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Constitutionnal thinness women and healthy volonteers(women)
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| Name | Affiliation | Role |
|---|---|---|
| Bruno ESTOUR, MD PhD | CHU de Saint-Etienne | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CRNH Auvergne | Clermont-Ferrand | 63000 | France | |||
| CRNH Rhône-Alpes |
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| ID | Term |
|---|---|
| D013851 | Thinness |
| D052439 | Lipid Metabolism Disorders |
| ID | Term |
|---|---|
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D008659 | Metabolic Diseases |
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muscle tissue fat tissue
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| After one month of lipid overnutrition |
| gastrointestinal hormone level | Serum level of GLP1 | After one month of lipid overnutrition |
| Anthropometric parameter | Weight | After one month of lipid overnutrition |
| Anthropometric parameter | Fat mass | After one month of lipid overnutrition |
| gastrointestinal hormone level | Serum level of ghréline | After one month of lipid overnutrition |
| gastrointestinal hormone level | Serum level of PYY | After one month of lipid overnutrition |
| Lyon |
| 69000 |
| France |
| CHU de Saint-Etienne | Saint-Etienne | 42055 | France |
| D009750 | Nutritional and Metabolic Diseases |