The Effect of Mifepristone on the Expression of Cervical Prostaglandin EP3 Receptors

Cervical Prostaglandin EP3 Receptor mRNA Expression 48 Hours After Administration of Mifepristone

The purpose of this study is to determine the effect of mifepristone on the expression of three cervical EP3 receptor isoforms (EP3-2, EP3-3 and EP3-6) in pregnant women ≤63 days gestational age.

Inclusion Criteria:

• good general health
• ≥18 years old
• seeking termination of a viable intrauterine pregnancy of ≤63 days, without any evidence of a threatened or spontaneous abortion

Exclusion Criteria:

• medical problems
• confirmed or suspected ectopic pregnancy
• having taken medications in the seven days prior to enrollment that would affect PG synthesis or metabolism of mifepristone