The IRB considered our trial risky. Although there were debates between investigators and IRB, we terminated our trial in accordance with the suggestion of IRB.

The purpose of this study is to determine whether simultaneously using the traditional Chinese medicine, Si-Ni-Tang, is more effective in the treatment of septic shock patients.

Those with hemodynamic instability were the main population of the ICU patients, whether the exact etiology leading to the diseases. However, how to maintain adequate hemodynamic status in order to keep the patients with well organs perfusion is the main issue of the intensive care physicians. The choices of vasoactive drugs in the guidelines or experts' suggestions nowadays used are still limited in the western medicine. Si-Ni-Tang, a remedy previously used in ancient China and now widely prescribed in Taiwan and China, is used for treating patients diagnosed as shock or heart failure. The investigators are eager to know if there existed any benefit via adding this drug to treat the septic shock patients. Therefore, the investigators designed a prospectively randomized double blind control trial to determine whether simultaneously using the traditional Chinese medicine, Si-Ni-Tang, is more effective in the treatment of septic shock patients.

Inclusion Criteria:

• Adult patients admitted to our intensive care units are enrolled if their disease diagnosis meets the definition of septic shock
• Using vasopressor now and the duration from initiation of vasopressor use to the entrance of the study is within 24 hours
• Nasogastric tube feeding

Exclusion Criteria:

• More than one kind of vasopressor is administrated
• Patients with extremely poor gastrointestinal function and can not tolerate diet feeding
• Acute myocardial infarction
• Patients with evidence of major bleeding
• Expected surgical intervention or scheduled surgery in the subsequent one week
• Patients who received digoxin for arrhythmia in the past one week