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To proof the feasibility and safety of EBUS guided transbronchial cryo biopsies in peripheral lung lesions
Solitary pulmonary nodule are a diagnostic dilemma. Nowadays not only the basic tissue diagnosis is necessary, molecular signals are state of the art. Therefore more tissue is necessary. With a cryoprobe the amount of tissue is increased compared to the classical forceps biopsy.
Until now, the use of the cryoprobe ism´t show in peripheral lung tissue.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cryo biospy | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cryo biopsy | Procedure | Cryoprobe, Erbe Company |
|
|
| Measure | Description | Time Frame |
|---|---|---|
| Safety | Number of Participants with Adverse Events as a Measure of Safety Detailed analysis of number of Pneumothoraces and number of bleeding complication | 24 h after intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Efficacy | Diagnostic yield of the different biopsy techniques in establishing a specific diagnosis of the lesion | 48 h after intervention |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Felix JF Herth, MD, PhD | Contact | +49-6221 396 | 1200 | felix.herth@thoraxklinik-heidelberg.de |
| Ralf Eberhardt, MD | Contact | +49 6221-396 | 8204 | ralf.eberhardt@thoraxklinik-heidelberg.de |
| Name | Affiliation | Role |
|---|---|---|
| Felix JF Herth, MD, PhD | Thoraxklinik, Universityof Heidelberg | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Pneumology and Critical Care medicine | Recruiting | Heidelberg | Baden-Wurttemberg | 69190 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20802352 | Background | Eberhardt R, Kahn N, Gompelmann D, Schumann M, Heussel CP, Herth FJ. LungPoint--a new approach to peripheral lesions. J Thorac Oncol. 2010 Oct;5(10):1559-63. doi: 10.1097/JTO.0b013e3181e8b308. | |
| 20477337 | Background | Eberhardt R, Gompelmann D, Herth FJ. Electromagnetic navigation in lung cancer: research update. Expert Rev Respir Med. 2009 Oct;3(5):469-73. doi: 10.1586/ers.09.36. |
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| ID | Term |
|---|---|
| D003074 | Solitary Pulmonary Nodule |
| ID | Term |
|---|---|
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
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| 19648733 | Background | Eberhardt R, Morgan RK, Ernst A, Beyer T, Herth FJ. Comparison of suction catheter versus forceps biopsy for sampling of solitary pulmonary nodules guided by electromagnetic navigational bronchoscopy. Respiration. 2010;79(1):54-60. doi: 10.1159/000232394. Epub 2009 Jul 31. |
| 20203535 | Background | Eberhardt R, Kahn N, Herth FJ. 'Heat and destroy': bronchoscopic-guided therapy of peripheral lung lesions. Respiration. 2010;79(4):265-73. doi: 10.1159/000284015. Epub 2010 Feb 10. |
| 23900983 | Derived | Schuhmann M, Bostanci K, Bugalho A, Warth A, Schnabel PA, Herth FJ, Eberhardt R. Endobronchial ultrasound-guided cryobiopsies in peripheral pulmonary lesions: a feasibility study. Eur Respir J. 2014 Jan;43(1):233-9. doi: 10.1183/09031936.00011313. Epub 2013 Jul 30. |