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| Name | Class |
|---|---|
| German Federal Ministry of Education and Research | OTHER_GOV |
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The study will investigate whether dietary modification could provide positive effects on brain functions in elderly people with mild cognitive impairment.
The age-related degradation of cognitive functions even to the point of neurodegenerative disorders such as Alzheimer's disease are a growing public-health concern with devastating effects.
Referring to animal data, empirical studies, and pilot human trials, dietary modification (caloric restriction, omega-3 fatty acids and resveratrol) should improve cognitive functions such as learning and memory. To test this hypothesis, the researchers study general brain functions in elderly subjects (50-80 years old) with mild cognitive impairment.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Caloric restriction | Experimental |
| |
| omega-3 supplementation | Experimental |
| |
| resveratrol supplementation | Experimental |
| |
| placebo | Placebo Comparator |
| |
| 2nd step: intervention + physical /cognitive training | Experimental | most effective dietary intervention plus physical and cognitive training |
|
| 2nd step: most effective dietary intervention plus control | Placebo Comparator | most effective dietary intervention plus control |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| caloric restriction | Behavioral | 6 months of caloric restriction (15 %) |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Alzheimer's Disease Assessment Scale - cognitive subscale | Prior to intervention and after 6 months of intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Functional/Structural brain changes | Prior to intervention and after 6 months of intervention | |
| Plasma biomarkers | Prior to intervention and after 6 months of intervention |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Agnes Floeel, Prof. | Charité University Berlin | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Neurology, Charité Universitätsmedizin Berlin | Berlin | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26433119 | Result | Kobe T, Witte AV, Schnelle A, Lesemann A, Fabian S, Tesky VA, Pantel J, Floel A. Combined omega-3 fatty acids, aerobic exercise and cognitive stimulation prevents decline in gray matter volume of the frontal, parietal and cingulate cortex in patients with mild cognitive impairment. Neuroimage. 2016 May 1;131:226-38. doi: 10.1016/j.neuroimage.2015.09.050. Epub 2015 Oct 1. | |
| 28326010 |
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| omega-3 supplementation |
| Behavioral |
6 months of omega-3 supplementation |
|
| resveratrol supplementation | Behavioral | 6 months of resveratrol supplementation |
|
| Placebo | Behavioral | 6 months of placebo intake |
|
| 2nd step: intervention + physical / cognitive training | Behavioral | most effective dietary intervention plus physical and cognitive training |
|
| 2nd step: intervention + control | Behavioral | most effective dietary intervention plus control |
|
| Result |
| Kobe T, Witte AV, Schnelle A, Tesky VA, Pantel J, Schuchardt JP, Hahn A, Bohlken J, Grittner U, Floel A. Impact of Resveratrol on Glucose Control, Hippocampal Structure and Connectivity, and Memory Performance in Patients with Mild Cognitive Impairment. Front Neurosci. 2017 Mar 7;11:105. doi: 10.3389/fnins.2017.00105. eCollection 2017. |
| 27511061 | Result | Witte AV, Kobe T, Graunke A, Schuchardt JP, Hahn A, Tesky VA, Pantel J, Floel A. Impact of leptin on memory function and hippocampal structure in mild cognitive impairment. Hum Brain Mapp. 2016 Dec;37(12):4539-4549. doi: 10.1002/hbm.23327. Epub 2016 Aug 11. |
| 27037094 | Result | Wirth M, Pichet Binette A, Brunecker P, Kobe T, Witte AV, Floel A. Divergent regional patterns of cerebral hypoperfusion and gray matter atrophy in mild cognitive impairment patients. J Cereb Blood Flow Metab. 2017 Mar;37(3):814-824. doi: 10.1177/0271678X16641128. Epub 2016 Jul 20. |
| 26912492 | Result | Kobe T, Witte AV, Schnelle A, Grittner U, Tesky VA, Pantel J, Schuchardt JP, Hahn A, Bohlken J, Rujescu D, Floel A. Vitamin B-12 concentration, memory performance, and hippocampal structure in patients with mild cognitive impairment. Am J Clin Nutr. 2016 Apr;103(4):1045-54. doi: 10.3945/ajcn.115.116970. Epub 2016 Feb 24. |
| ID | Term |
|---|---|
| D060825 | Cognitive Dysfunction |
| ID | Term |
|---|---|
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D031204 | Caloric Restriction |
| D012149 | Restraint, Physical |
| D000091942 | Cognitive Training |
| ID | Term |
|---|---|
| D004035 | Diet Therapy |
| D044623 | Nutrition Therapy |
| D013812 | Therapeutics |
| D002149 | Energy Intake |
| D004032 | Diet |
| D009747 | Nutritional Physiological Phenomena |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D032763 | Behavior Control |
| D007103 | Immobilization |
| D008919 | Investigative Techniques |
| D000066530 | Neurological Rehabilitation |
| D012046 | Rehabilitation |
| D000359 | Aftercare |
| D003266 | Continuity of Patient Care |
| D005791 | Patient Care |
| D006296 | Health Services |
| D005159 | Health Care Facilities Workforce and Services |
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