Pelvic and Aortic-cava Lymphadenectomy Randomized for Ovarian Cancer

Pelvic and Aortic-cava Lymphadenectomy Randomized Phase III for Advanced Ovarian Cancer

It is a multicenter randomized trial of superior cleaning compared the absence of dissection in stage III patients with optimal surgical resection without retroperitoneal lymph node palpable.

Inclusion Criteria:

• Age> 18 years
• Karnofsky> 80, or ASA I-II
• Primary ovarian adenocarcinoma, or primitive peritoneal
• No retroperitoneal lymph node> 2cm (CT; MRI)
• Complete surgical staging
• Stage III-IV FIGO classification
• Indication of systemic chemotherapy before surgery or post surgery

Exclusion Criteria:

• Non Invasive Cancer
• non-epithelial or borderline cancer
• Pregnancy
• Previous pelvic lymphadenectomy or aortic-cava for a disease other than ovarian cancer
• Contraindication to Platinum and Paclitaxel
• Borderline Ovarian Tumor
• tumor recurrence
• Incomplete surgery, resectable lesion, Surgery sub optimal (R> 1cm)