This study is aimed to evaluate the performance of the Micromedic CD24 assay in identifying colorectal adenoma using Western blot and ELISA assays. These assays are designed to detect CD24 protein in peripheral blood leukocytes (PBL). Elevated levels of CD24 may be indicative of colorectal adenoma (inclusive of optically detectable early adenoma to late adenoma, and cancer).

Inclusion Criteria:

• Subject is 50 years old and above
• Subject is asymptomatic and referred for regular recommended screening colonoscopy or subject is referred due to suspicion of colon cancer, prior to beginning of any treatment (enriched population)
• Subject signed the informed consent

Exclusion Criteria:

• Subject has been previously diagnosed with any type of cancer
• Subject has been previously diagnosed with a colorectal abnormality such as colorectal adenoma, hyperplastic polyp or carcinoma
• Blood sample was not collected on the day of colonoscopy and prior to colonoscopy
• Subject has first degree family history of colorectal cancer
• Subject has active infection or inflammation as determined clinically at screening
• Subject is currently taking medications related to the previous exclusion criteria
• Subject has participated in, or is participating in, any investigational drug or device study within 30 days prior the date of colonoscopy and any additional study required test
• Pregnant or lactating woman

Subjects aged 50 years and above that are referred to colonoscopy assessment