Study of Induction Therapy With Mitoxantrone and Plasmapheresis to Treat Aggressive Multiple Sclerosis

Study of Combinative Effect of Induction Therapy With Mitoxantrone and Plasmapheresis to Treat Patients With Aggressive Multiple Sclerosis

The purpose of this study is to compare the effect of combinative induction therapy with mitoxantrone and plasmapheresis versus induction therapy with mitoxantrone alone in cases of aggressive multiple sclerosis

Inclusion Criteria:

• Aggressive multiple sclerosis in attack phase
• EDSS: 1-5
• No contraindication for mitoxantrone prescription
• No past history of mitoxantrone injection
• No history of corticosteroid and immunosuppressive therapy in last 3 months

Exclusion Criteria:

• Patient's incompliance
• Severe drug induced side effects