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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| bipolar depression | Experimental | unmedicated patients with bipolar depression receiving quetiapine treatment |
|
| Control | No Intervention | healthy controls matched for age, gender, and body mass index |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Quetiapine | Drug | oral tablet/25-600mg per day/once a day/six weeks |
|
| Measure | Description | Time Frame |
|---|---|---|
| Heart Rate Variability | heart rate variability parameters of time/frequency/complexity domains | Six weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Cardio-Respiratory Coupling | integrative parameters of interaction between neurocardiac dynamics and respiratory rhythm | Six weeks |
| Electroencephalographic Changes | Electrical brain activities measured by quantitative electroencephalography |
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Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jae Seung Chang, M.D., Ph.D. | Contact | 82-31-787-7437 | cjs0107@snu.ac.kr | |
| Ji Sun Kim, M.D. | Contact | 82-10-9933-1286 | ideal91@hanmail.net |
| Name | Affiliation | Role |
|---|---|---|
| Jae Seung Chang, M.D., Ph.D. | Seoul National University Bundang Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Neuropsychiatry, Seoul National University Bundang Hospital | Recruiting | Seongnam-si | Gyeonggi-do | 463-707 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20083149 | Background | Berger S, Boettger MK, Tancer M, Guinjoan SM, Yeragani VK, Bar KJ. Reduced cardio-respiratory coupling indicates suppression of vagal activity in healthy relatives of patients with schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2010 Mar 17;34(2):406-11. doi: 10.1016/j.pnpbp.2010.01.009. Epub 2010 Jan 18. | |
| 20538342 | Background |
| Label | URL |
|---|---|
| Click here for more information about recent updates on bipolar disorder research | View source |
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| ID | Term |
|---|---|
| D001714 | Bipolar Disorder |
| ID | Term |
|---|---|
| D000068105 | Bipolar and Related Disorders |
| D019964 | Mood Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D000069348 | Quetiapine Fumarate |
| ID | Term |
|---|---|
| D003987 | Dibenzothiazepines |
| D013841 | Thiazepines |
| D013846 | Thiepins |
| D013457 | Sulfur Compounds |
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| Six weeks |
| Severity of Mood Symptoms |
| Six weeks |
| Severity of Extrapyramidal Symptom Scale | Drug-Induced Extrapyramidal Symptom Scale | Six weeks |
| Bar KJ, Schuhmacher A, Hofels S, Schulz S, Voss A, Yeragani VK, Maier W, Zobel A. Reduced cardio-respiratory coupling after treatment with nortriptyline in contrast to S-citalopram. J Affect Disord. 2010 Dec;127(1-3):266-73. doi: 10.1016/j.jad.2010.05.010. Epub 2010 Jun 9. |
| 19427888 | Background | Chang JS, Yoo CS, Yi SH, Hong KH, Oh HS, Hwang JY, Kim SG, Ahn YM, Kim YS. Differential pattern of heart rate variability in patients with schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2009 Aug 31;33(6):991-5. doi: 10.1016/j.pnpbp.2009.05.004. Epub 2009 May 7. |
| 20138254 | Background | Kemp AH, Quintana DS, Gray MA, Felmingham KL, Brown K, Gatt JM. Impact of depression and antidepressant treatment on heart rate variability: a review and meta-analysis. Biol Psychiatry. 2010 Jun 1;67(11):1067-74. doi: 10.1016/j.biopsych.2009.12.012. Epub 2010 Feb 6. |
| 15219580 | Background | Kemp AH, Gray MA, Silberstein RB, Armstrong SM, Nathan PJ. Augmentation of serotonin enhances pleasant and suppresses unpleasant cortical electrophysiological responses to visual emotional stimuli in humans. Neuroimage. 2004 Jul;22(3):1084-96. doi: 10.1016/j.neuroimage.2004.03.022. |
| D009930 |
| Organic Chemicals |
| D006575 | Heterocyclic Compounds, 3-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |