Physical Activity for Reduction of Recurrence Rate After Adjuvant Chemotherapy for Localised Colorectal Carcinoma

Physical Activity for Reduction of Recurrence Rate After Adjuvant Chemotherapy for Localised Colorectal Carcinoma

• feasibility of physical activity
• increase of physical conversation
• Quality of Life (optional)
• vascular and metabolic effects

In this phase II pilot project the feasibility of a defined medical physical activity should be verified for increased physical conversation. The study is conducted multicentric (single group) with a study population of 30 patients. After completion of adjuvant chemotherapy the patients will participate a defined physical training, 3 times per week within a time period of 52 weeks. Planned study duration 2 years.

Inclusion Criteria:

• complete resected, histologically confirmed adeno carcinoma of colon or rectal and condition after (neo-)adjuvant therapy either in (1) stage III or (2) stage II with risk factor
• 4-16 weeks after the end of an adjuvant chemotherapy
• ECOG 0,1
• Age > 18 years
• adequate liver-, nephro- and hemogram parameters
• physical eligibility

Exclusion Criteria:

• significant comorbidities which exclude the participation
• evidence of local recurrence or distant metastases
• non-compliance of subject
• other malignancy within the last 5 years (except: skin basalioma, cervix carcinoma in situ)
• clinically significant cardiovascular diseases
• treatment with beta blocker without possibility of adjustment
• left bundle-branch block
• simultaneous chemotherapy or radiotherapy
• pregnancy