Incidence of Hepatitis B Virus (HBV) Reactivation in HBsAg Negative/HBcAb Positive Lymphoma Patients Treated With RCHOP

Incidence of HBV Reactivation in HBsAg Negative/HBcAb Positive Diffuse Large B Cell Lymphoma or High Grade Follicular Lymphoma Patients: A Prospective Study

The aim of this study is to identify the incidence of hepatitis B virus reactivation rate in Diffuse Large B Cell or high grade Follicular lymphoma patients with prior resolved hepatitis B undergoing RCHOP immuno-chemotherapy.

Inclusion Criteria:

• Naive DLBCL or high grade FL patients
• Age range 18-75 years old
• ECOG performance status 0-3
• Life expectancy of more than 3 months
• Adequate organ function
• HBsAg negative/HBcAb positive at baseline

Exclusion Criteria:

• Infection of HAV,HCV,HIV
• Pregnant or lactating women
• Serious uncontrolled diseases