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After having shown that postconditioning allowed a significant 36% reduction of infarct size as assessed by blood levels of myocardial enzymes in acute myocardial patients, the investigators objective is to assess the effect of postconditioning in acute myocardial infarction (AMI) patients on microvascular obstruction lesions defined by cardiac MRI images.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | No Intervention | 22 controls patients without post conditionment | |
| Intervention | Experimental | 22 posconditioned patients |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| postconditioning | Procedure | Direct postconditioning (brief repeated cycle of 4 occlusion and desocclusion of the initially occluded culprit coronary artery) after primary direct stenting. |
| Measure | Description | Time Frame |
|---|---|---|
| Extent of the area of microvascular obstruction | Extent of the area of microvascular obstruction defined on post-gadolinium CMR images realized 48-72 hours after admission in each group | 5 days |
| Measure | Description | Time Frame |
|---|---|---|
| Size of the myocardial infarction | Size of the myocardial infarction defined on post-gadolinium CMR images realized 48-72 hours after admission in each group. | 5 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Pierre CROISILLE, MD | Hospices Civils de Lyon | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospices Civils de Lyon | Lyon | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22676937 | Result | Thuny F, Lairez O, Roubille F, Mewton N, Rioufol G, Sportouch C, Sanchez I, Bergerot C, Thibault H, Cung TT, Finet G, Argaud L, Revel D, Derumeaux G, Bonnefoy-Cudraz E, Elbaz M, Piot C, Ovize M, Croisille P. Post-conditioning reduces infarct size and edema in patients with ST-segment elevation myocardial infarction. J Am Coll Cardiol. 2012 Jun 12;59(24):2175-81. doi: 10.1016/j.jacc.2012.03.026. |
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| ID | Term |
|---|---|
| D015428 | Myocardial Reperfusion Injury |
| D009203 | Myocardial Infarction |
| ID | Term |
|---|---|
| D009202 | Cardiomyopathies |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D017202 | Myocardial Ischemia |
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| ID | Term |
|---|---|
| D057775 | Ischemic Postconditioning |
| ID | Term |
|---|---|
| D013812 | Therapeutics |
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| D014652 |
| Vascular Diseases |
| D015427 | Reperfusion Injury |
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D007238 | Infarction |
| D007511 | Ischemia |
| D009336 | Necrosis |