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For the patient with acute dyspnea in the ED, early differentiation between CHF and non-CHF causes is essential for proper management. The capacity to triage patients quickly and accurately has a beneficial impact upon outcome, disposition, stratification and length of stay in the ED and required length of hospital admission.
The ability to assess pulmonary status rapidly by quantitative regional vibration technology offers significant potential advantage for earlier diagnosis. The VRI technique may provide a quick and accurate method of differentiating between dyspnea due to HF and dyspnea due to pulmonary causes; thereby improving management and outcomes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ED patients presenting with dyspnea |
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| Measure | Description | Time Frame |
|---|---|---|
| Assess the ability of the VRI to improve clinical outcomes via accurate, early classification of the cause of acute dyspnea as HF or other (i.e. COPD, PE etc). | The primary efficacy analysis set (PEAS) consists of all patients who have Gold Standard (GS) diagnosis (CHF/non-CHF) & VRI records.
| Baseline testing at ED presentation |
| Measure | Description | Time Frame |
|---|---|---|
| Assess the agreement to aid in classifying the cause of acute dyspnea as HF or other of the VRI in comparison to BNP/NTproBNP assays. | The secondary efficacy analysis set (SEAS) consists of all patients who have final diagnosis (CHF/non-CHF), BNP/NT-proBNP & VRI results.
|
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Inclusion Criteria:
Able and willing to provide Informed Consent;
->40 years of age;
Estimated Body Mass Index >19;
Patient presented to the emergency department with a chief complaint of acute dyspnea.
Exclusion Criteria:
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Patients presenting to the ED with acute dyspnea who are greater than 40 years of age and consisting of both male and females
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Charles V. Pollack, MD | Contact | 215-829-7549 | cvpollack@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Charles V. Pollack, MD | Pennsylvania Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Christiana Care Health System | Recruiting | Newark | Delaware | 19718 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 18773329 | Background | Wang Z, Bartter T, Baumann BM, Abouzgheib W, Chansky ME, Jean S. Asynchrony between left and right lungs in acute asthma. J Asthma. 2008 Sep;45(7):575-8. doi: 10.1080/02770900802017744. | |
| 19085584 | Background | Guntupalli KK, Reddy RM, Loutfi RH, Alapat PM, Bandi VD, Hanania NA. Evaluation of obstructive lung disease with vibration response imaging. J Asthma. 2008 Dec;45(10):923-30. doi: 10.1080/02770900802395496. |
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| ID | Term |
|---|---|
| D004417 | Dyspnea |
| D029424 | Pulmonary Disease, Chronic Obstructive |
| D001249 | Asthma |
| ID | Term |
|---|---|
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
| D012818 | Signs and Symptoms, Respiratory |
| D012816 | Signs and Symptoms |
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Blood drawn for BNP testing
| Baseline testing at ED presentation |
| Assess the ability of the VRI to aid in classifying the cause of acute dyspnea as HF or COPD | The tertiary efficacy analysis set (TEAS) consists of all patients who have final diagnosis (CHF/COPD) & VRI results. -Similar to the previous objectives - accuracy (with the GS) and agreement rates (with BNP/NT-proBNP); comparisons based only on CHF and COPD patients. | Baseline testing at ED presentation |
| Evaluate the ability of the VRI to monitor changes in clinical status following treatment in comparison with other standard testing methods (e.g. ECG, serial chest x-rays, etc.) | The fourth efficacy analysis set consists of patients who have baseline & after treatment follow-up clinical data & VRI recordings.
| Baseline testing and repeated testing after 2 hours |
| University of Nevada School of Medicine | Not yet recruiting | Las Vegas | Nevada | 89106 | United States |
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| Mount Sinai School of Medicine | Recruiting | New York | New York | 10029 | United States |
|
| Lincoln Medical and Mental Health Center | Recruiting | The Bronx | New York | 10451 | United States |
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| Metrohealth Medical Center | Recruiting | Cleveland | Ohio | 44122 | United States |
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| Pennsylvania Hospital | Recruiting | Philadelphia | Pennsylvania | 19107 | United States |
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| Baylor College of Medicine | Not yet recruiting | Houston | Texas | 77030 | United States |
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| Beilinson Hospital, Rabin Medical Center | Not yet recruiting | Petah Tikva | 49100 | Israel |
|
| 17551264 | Background | Dellinger RP, Parrillo JE, Kushnir A, Rossi M, Kushnir I. Dynamic visualization of lung sounds with a vibration response device: a case series. Respiration. 2008;75(1):60-72. doi: 10.1159/000103558. Epub 2007 Jun 4. |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D001982 | Bronchial Diseases |
| D012130 | Respiratory Hypersensitivity |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |