Metformin for Treatment Antipsychotic Induced Amenorrhea in Female Schizophrenic Patients

Metformin for Treatment Antipsychotic Induced Amenorrhea in Female Schizophrenic Patients: a Double Blind, Placebo-controlled Study

Antipsychotics such as risperidone could induce amenorrhea in schizophrenic patients. The investigators conducted a randomized, placebo-controlled study to test the efficacy of metformin for antipsychotic induced amenorrhea in schizophrenia patients.

Inclusion Criteria:

• schizophrenia patient
• amenorrhea for more than three months after antipsychotic treatment

Exclusion Criteria:

• liver or renal diseases
• pregnant or lactating women
• cardiovascular diseases
• hypertension or diabetes mellitus