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| ID | Type | Description | Link |
|---|---|---|---|
| R01NS069763-01 | Other Grant/Funding Number | NINDS |
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| Name | Class |
|---|---|
| Massachusetts General Hospital | OTHER |
| Columbia University | OTHER |
| University of Maryland | OTHER |
| Georgetown University |
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The purpose of this study is to find risk factors for hemorrhagic stroke, specifically intracerebral hemorrhage (ICH), among Caucasians, African Americans, and Hispanics.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cases | 3000 Cases | ||
| Controls | 3000 Controls |
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Inclusion Criteria:
All cases must meet the following eligibility criteria:
Exclusion Criteria:
Exclusion Criteria:
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Our purpose is to enroll 1000 cases of ICH among whites, 1000 cases of ICH among blacks, and 1000 cases of ICH among Hispanics.
3000 controls matched to cases by race/ethnicity, age (+/- 5 years), gender, and geographic location.
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| Name | Affiliation | Role |
|---|---|---|
| Daniel Woo, MD, MS | University of Cincinnati | Principal Investigator |
| Matthew Flaherty, MD | University of Cincinnati | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Arizona | Tucson | Arizona | 85724 | United States | ||
| University of Southern California |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 8784113 | Background | Taylor TN, Davis PH, Torner JC, Holmes J, Meyer JW, Jacobson MF. Lifetime cost of stroke in the United States. Stroke. 1996 Sep;27(9):1459-66. doi: 10.1161/01.str.27.9.1459. | |
| 11988589 | Background | Woo D, Sauerbeck LR, Kissela BM, Khoury JC, Szaflarski JP, Gebel J, Shukla R, Pancioli AM, Jauch EC, Menon AG, Deka R, Carrozzella JA, Moomaw CJ, Fontaine RN, Broderick JP. Genetic and environmental risk factors for intracerebral hemorrhage: preliminary results of a population-based study. Stroke. 2002 May;33(5):1190-5. doi: 10.1161/01.str.0000014774.88027.22. |
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| OTHER |
| Wake Forest University | OTHER |
| Emory University | OTHER |
| University of Miami | OTHER |
| University of Illinois at Chicago | OTHER |
| University of Texas, Southwestern Medical Center at Dallas | OTHER |
| The University of Texas Health Science Center, Houston | OTHER |
| The University of Texas Health Science Center at San Antonio | OTHER |
| University of New Mexico | OTHER |
| University of Arizona | OTHER |
| University of Southern California | OTHER |
| St. Luke's-Roosevelt Hospital Center | OTHER |
| University of California, San Francisco | OTHER |
| Duke University | OTHER |
| University of Virginia | OTHER |
| National Institute of Neurological Disorders and Stroke (NINDS) | NIH |
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whole blood
| Los Angeles |
| California |
| 90033 |
| United States |
| Georgetown University | Washington D.C. | District of Columbia | 20007 | United States |
| University of Miami - Biorepository | Miami | Florida | 33136 | United States |
| University of Miami | Miami | Florida | 33136 | United States |
| Emory University | Atlanta | Georgia | 30303 | United States |
| University of Illinois | Chicago | Illinois | 60612 | United States |
| University of Maryland | Baltimore | Maryland | 21201 | United States |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | United States |
| University of New Mexico | Albuquerque | New Mexico | 87131 | United States |
| Columbia University | New York | New York | 10032 | United States |
| Wake Forest University | Winston-Salem | North Carolina | 27157 | United States |
| University of Texas Southwestern Medical Center at Dallas | Dallas | Texas | 75390 | United States |
| University of Texas Medical School at Houston | Houston | Texas | 77030 | United States |
| University of Texas Health Science Center at San Antonio | San Antonio | Texas | 78229 | United States |
| 14757893 | Background | Kissela B, Schneider A, Kleindorfer D, Khoury J, Miller R, Alwell K, Woo D, Szaflarski J, Gebel J, Moomaw C, Pancioli A, Jauch E, Shukla R, Broderick J. Stroke in a biracial population: the excess burden of stroke among blacks. Stroke. 2004 Feb;35(2):426-31. doi: 10.1161/01.STR.0000110982.74967.39. |
| 12843343 | Background | Hardie K, Hankey GJ, Jamrozik K, Broadhurst RJ, Anderson C. Ten-year survival after first-ever stroke in the perth community stroke study. Stroke. 2003 Aug;34(8):1842-6. doi: 10.1161/01.STR.0000082382.42061.EE. Epub 2003 Jul 3. |
| 2718196 | Background | Broderick JP, Phillips SJ, Whisnant JP, O'Fallon WM, Bergstralh EJ. Incidence rates of stroke in the eighties: the end of the decline in stroke? Stroke. 1989 May;20(5):577-82. doi: 10.1161/01.str.20.5.577. |
| 8421201 | Background | Broderick JP, Brott T, Tomsick T, Miller R, Huster G. Intracerebral hemorrhage more than twice as common as subarachnoid hemorrhage. J Neurosurg. 1993 Feb;78(2):188-91. doi: 10.3171/jns.1993.78.2.0188. |
| 14716702 | Background | Barber M, Stott DJ. Validity of the Telephone Interview for Cognitive Status (TICS) in post-stroke subjects. Int J Geriatr Psychiatry. 2004 Jan;19(1):75-9. doi: 10.1002/gps.1041. |
| 12673608 | Background | de Jager CA, Budge MM, Clarke R. Utility of TICS-M for the assessment of cognitive function in older adults. Int J Geriatr Psychiatry. 2003 Apr;18(4):318-24. doi: 10.1002/gps.830. |
| 14258950 | Background | MAHONEY FI, BARTHEL DW. FUNCTIONAL EVALUATION: THE BARTHEL INDEX. Md State Med J. 1965 Feb;14:61-5. No abstract available. |
| 13432835 | Background | RANKIN J. Cerebral vascular accidents in patients over the age of 60. II. Prognosis. Scott Med J. 1957 May;2(5):200-15. doi: 10.1177/003693305700200504. No abstract available. |
| 15452298 | Background | Flibotte JJ, Hagan N, O'Donnell J, Greenberg SM, Rosand J. Warfarin, hematoma expansion, and outcome of intracerebral hemorrhage. Neurology. 2004 Sep 28;63(6):1059-64. doi: 10.1212/01.wnl.0000138428.40673.83. |
| 17372123 | Background | Goldstein JN, Fazen LE, Snider R, Schwab K, Greenberg SM, Smith EE, Lev MH, Rosand J. Contrast extravasation on CT angiography predicts hematoma expansion in intracerebral hemorrhage. Neurology. 2007 Mar 20;68(12):889-94. doi: 10.1212/01.wnl.0000257087.22852.21. |
| 19242340 | Background | Kumar MA, Rost NS, Snider RW, Chanderraj R, Greenberg SM, Smith EE, Rosand J. Anemia and hematoma volume in acute intracerebral hemorrhage. Crit Care Med. 2009 Apr;37(4):1442-7. doi: 10.1097/CCM.0b013e31819ced3a. |
| 8996478 | Background | Brott T, Broderick J, Kothari R, Barsan W, Tomsick T, Sauerbeck L, Spilker J, Duldner J, Khoury J. Early hemorrhage growth in patients with intracerebral hemorrhage. Stroke. 1997 Jan;28(1):1-5. doi: 10.1161/01.str.28.1.1. |
| 16636233 | Background | Davis SM, Broderick J, Hennerici M, Brun NC, Diringer MN, Mayer SA, Begtrup K, Steiner T; Recombinant Activated Factor VII Intracerebral Hemorrhage Trial Investigators. Hematoma growth is a determinant of mortality and poor outcome after intracerebral hemorrhage. Neurology. 2006 Apr 25;66(8):1175-81. doi: 10.1212/01.wnl.0000208408.98482.99. |
| 18480205 | Background | Mayer SA, Brun NC, Begtrup K, Broderick J, Davis S, Diringer MN, Skolnick BE, Steiner T; FAST Trial Investigators. Efficacy and safety of recombinant activated factor VII for acute intracerebral hemorrhage. N Engl J Med. 2008 May 15;358(20):2127-37. doi: 10.1056/NEJMoa0707534. |
| 40055853 | Derived | Behymer TP, Sekar P, Demel SL, Aziz YN, Coleman ER, Williamson BJ, Stanton RJ, Sawyer RP, Turner AC, Vagal VS, Osborne J, Gilkerson LA, Comeau ME, Flaherty ML, Langefeld CD, Woo D. Psychosocial Stress and Risk for Intracerebral Hemorrhage in the ERICH (Ethnic/Racial Variations of Intracerebral Hemorrhage) Study. J Am Heart Assoc. 2025 Mar 18;14(6):e024457. doi: 10.1161/JAHA.121.024457. Epub 2025 Mar 7. |
| 39069917 | Derived | Ridha M, Hannawi Y, Murthy S, Carvalho Poyraz F, Kumar A, Park S, Roh D, Sekar P, Woo D, Burke J. Premorbid Blood Pressure Control Modifies Risk of DWI Lesions With Acute Blood Pressure Reduction in Intracerebral Hemorrhage. Hypertension. 2024 Oct;81(10):2113-2123. doi: 10.1161/HYPERTENSIONAHA.124.23271. Epub 2024 Jul 29. |
| 35443984 | Derived | Ng Y, Qi W, King NKK, Christianson T, Krishnamoorthy V, Shah S, Divani A, Bettin M, Coleman ER, Flaherty ML, Walsh KB, Testai FD, McCauley JL, Gilkerson LA, Langefeld CD, Behymer TP, Woo D, James ML. Initial antihypertensive agent effects on acute blood pressure after intracerebral haemorrhage. Stroke Vasc Neurol. 2022 Oct;7(5):367-374. doi: 10.1136/svn-2021-001101. Epub 2022 Apr 20. |
| 32126942 | Derived | Liu L, Fuller M, Behymer TP, Ng Y, Christianson T, Shah S, King NKK, Woo D, James ML. Selective Serotonin Reuptake Inhibitors and Intracerebral Hemorrhage Risk and Outcome. Stroke. 2020 Apr;51(4):1135-1141. doi: 10.1161/STROKEAHA.119.028406. Epub 2020 Mar 4. |
| 28710330 | Derived | James ML, Langefeld CD, Sekar P, Moomaw CJ, Elkind MSV, Worrall BB, Sheth KN, Martini SR, Osborne J, Woo D; ERICH Investigators. Assessment of the interaction of age and sex on 90-day outcome after intracerebral hemorrhage. Neurology. 2017 Sep 5;89(10):1011-1019. doi: 10.1212/WNL.0000000000004255. Epub 2017 Jul 14. |
| 27737957 | Derived | Walsh KB, Woo D, Sekar P, Osborne J, Moomaw CJ, Langefeld CD, Adeoye O. Untreated Hypertension: A Powerful Risk Factor for Lobar and Nonlobar Intracerebral Hemorrhage in Whites, Blacks, and Hispanics. Circulation. 2016 Nov 8;134(19):1444-1452. doi: 10.1161/CIRCULATIONAHA.116.024073. Epub 2016 Oct 13. |
| ID | Term |
|---|---|
| D002543 | Cerebral Hemorrhage |
| D020521 | Stroke |
| ID | Term |
|---|---|
| D020300 | Intracranial Hemorrhages |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D006470 | Hemorrhage |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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