Prospective Cohort Study With Central Nervous System Evaluation in Diffuse Large B-cell Lymphoma

Prospective Cohort Study With Risk-adapted Central Nervous System Evaluation in Diffuse Large B-cell Lymphoma

This study is to evaluate the incidence of central nervous system (CNS) relapse or metastasis in patients with diffuse large B-cell lymphoma.

We dichotomize patients according to the risk of CNS involvement. Then, we perform CNS evaluation in patients at risk of CNS involvement. We prospectively monitor whether CNS relapse or metastasis occurs in patients with diffuse large B-cell lymphoma

Inclusion Criteria:

1. Newly diagnosed patients with diffuse large B cell lymphoma
2. > 20 years
3. life expectancy more than 6 months
4. Written informed consent

Exclusion Criteria:

1. Refusal to informed consent
2. Lymphomas other than diffuse large B cell lymphoma
3. Primary CNS lymphoma