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| Name | Class |
|---|---|
| Adelphi Real World | INDUSTRY |
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Previous publications have indicated that Allergic Rhinitis (AR) patients suffering from both ocular and nasal symptoms have a greater burden of illness and lower quality of life than patients suffering from nasal symptoms alone. Fluticasone furoate (FF) acts against both nasal and ocular symptoms. The purpose of this study was to evaluate the differences in symptom control (both perceptually and objectively) and resource use for patients with current seasonal AR.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| FF | Cohort of patients receiving fluticasome furoate |
| |
| MF | cohort of patients on mometasone furoate |
| |
| FP | cohort of patients receiving fluticasone propionate |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Fluticasone furoate | Drug | cohort of patients receiving fluticasone furate |
|
| Measure | Description | Time Frame |
|---|---|---|
| Evaluate the differences in Symtom Free Days (SFD) in patients receiving FF, MF or FP | 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Evaluate the differences in Quality of Life (mini-Rhinoconjunctivitis Quality of Life Questionnaire) in patients receiving FF, MF or FP | 4 weeks | |
| Evaluate the differences in the number of AR treatments used by patients receiving FF, MF or FP | 4 weeks |
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Patient Inclusion Criteria:
Exclusion Criteria:
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Inclusion criteria for physicians:
Qualified after 1965
See 3 or more AR patients per week
Personally responsible for treatment decisions for patients with AR
Gave consent to participate to complete all tasks for the study duration
90 Primary Care Physicians and 45 allergists, each prospectively recruit 4 consecutive patients with SAR who provided consent to participate, for a total of 540 patients. Each physician completed a patient record form for 2 patients on fluticasone furate, 1 patient on mometasone furate and 1 patient on fluticasone propionate.
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| Name | Affiliation | Role |
|---|---|---|
| GSK Clinical Trials | GlaxoSmithKline | Study Director |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 17927672 | Background | Higgins V, Kay S, Small M. Physician and patient survey of allergic rhinitis: methodology. Allergy. 2007;62 Suppl 85:6-8. doi: 10.1111/j.1398-9995.2007.01547.x. | |
| Result | Gueron B; Demoly P; Piercy J; Small M. A comparison of patients on Avamys vs Nasonex and Flixonase for Quality of Life and Symptoms Free Days in 3 European countries [Poster 380]. Presented at: XXIXth Congress of the European Academy of Allergy and Clinical Immunology, June 2010, London | ||
| 24107462 |
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| mometasone furoate | Drug | cohort receiving mometasone furoate |
|
|
| fluticasone propionate | Drug | cohort of patients on fluticasone propionate |
|
|
| Evaluate the differences in the number of non-prescribed treatments used by patients receiving FF, MF or FP | 4 weeks |
| Evaluate the differences in the cost of non-prescribed treatments used by patients receiving FF, MF or FP | 4 weeks |
| Evaluate the differences in the Pittsburgh Sleep Quality Index in patients receiving FF, MF or FP | 4 weeks |
| Evaluate the differences in productivitiy (Work Productivity and Activity Impairment Questionnaire) of patients receiving FF, MF or FP | 4 weeks |
| Evaluate the differences in number of work day lost by patients receiving FF, MF or FP | 4 weeks |
| Evaluate the differences in the number of physician visits (as reported by patient and doctor) by patients receiving FF, MF or FP | 4 weeks |
| Derived |
| Small M, Piercy J, Demoly P, Marsden H. Burden of illness and quality of life in patients being treated for seasonal allergic rhinitis: a cohort survey. Clin Transl Allergy. 2013 Oct 9;3(1):33. doi: 10.1186/2045-7022-3-33. |
| ID | Term |
|---|---|
| D012221 | Rhinitis, Allergic, Perennial |
| D065631 | Rhinitis, Allergic |
| ID | Term |
|---|---|
| D012220 | Rhinitis |
| D009668 | Nose Diseases |
| D012140 | Respiratory Tract Diseases |
| D012130 | Respiratory Hypersensitivity |
| D010038 | Otorhinolaryngologic Diseases |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |
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| ID | Term |
|---|---|
| C523187 | fluticasone furoate |
| D000068656 | Mometasone Furoate |
| D000068298 | Fluticasone |
| ID | Term |
|---|---|
| D011244 | Pregnadienediols |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D000730 | Androstadienes |
| D000736 | Androstenes |
| D000731 | Androstanes |
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