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The aim of the present study was to compare the effect of aqueous extract of garlic with nystatin mouthwash in denture stomatitis.
Denture stomatitis is the most common form of chronic oral candidiasis manifested as chronic inflammation of the mucous membrane t supporting the movable prosthesis that may have a local or systemic nature. This inflammation is presented as mucous erythema and occasionally with pain and burning. The standard treatment for denture stomatitis is administration of nystatin which is accompanied with complications such as bitter taste as well as the high number of drug application that result in reduced tendency of patients in using this medication hence, efforts are continuously being made to substitute other types of therapies for this condition.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| drug: garlic extract, nystatin | Other | Drug: garlic extract 40mg/dl or nystatin suspension 100000 iu/ml tid for one month Patients had been clinically with denture stomatitis and confirmed by oral medicine specialist were selected for the study. Gender, age, medical history, erythema types, size, and other treatment used for this disease were recorded. Local ethical committee approval was obtained before the trial started and all patients gave written informed consent. Patients were randomly divided into two groups .First group received garlic extract and second group used nystatin suspension for 1 month. Each patients was examined at the beginning of the therapy ,and then every 1 weeks up to 1 months . |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| garlic , nystatin | Drug | mouthwash |
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| Measure | Description | Time Frame |
|---|---|---|
| reduction of diameter of erythematous lesion under denture | measuring erythematous lesion by visual and then photography and a colis | first week |
| Measure | Description | Time Frame |
|---|---|---|
| complete relief of erythematous lesions | fourth week |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| mahin bakhshi, DDS,MS | Qazvin University of Medical Science | Study Chair |
| Jamileh bigom Taheri, DDS/MS | Shahid Beheshti University of Medical Science | Study Director |
| Samira Basir Shabestari, DDS/MS | QUMS | Principal Investigator |
| Rozbeh Pahlevan, DDS | QUMS | Principal Investigator |
| Anet Tanic, DDS | QUMS | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| QUMS | Qazvin | Qazvin Province | Iran |
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| ID | Term |
|---|---|
| D013282 | Stomatitis, Denture |
| ID | Term |
|---|---|
| D013280 | Stomatitis |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
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| ID | Term |
|---|---|
| D009761 | Nystatin |
| ID | Term |
|---|---|
| D018942 | Macrolides |
| D007783 | Lactones |
| D009930 | Organic Chemicals |
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