A Surgical Approach to the Management of Type II Diabetes Mellitus in Patients With a BMI Between 25-35 kg/m2

A Surgical Approach to the Management of Type II Diabetes Mellitus in Patients With a BMI Between 25-35 kg/m2

The purpose of the study is to determine if by performing surgery we can cure Type II Diabetes.

The surgical procedures:

1. a sleeve gastrectomy, cutting out a portion of the stomach, which provides restriction of caloric intake and rapid gastric emptying.
2. ileal transposition which involves repositioning a 150cm segment of the ileum into the jejunum causing improved glucose homeostasis.

Inclusion Criteria:

• age- 21-55 years.
• Body Mass Index between 25-35 kf/m2.
• currently being treated for type 2 diabetes mellitus with oral hypoglycemic, insulin or both for the at least 3 years.
• Documented HbA1c>7.5% for at least 3 months.
• Stable weight for 3 months (+/-)
• Evidence of stable medical treatment for diabetes over the past 12 months.
• Able to provide informed consent -Female subject agrees to participate in accepted birth control methods -

Exclusion Criteria:

• Type I diabetes/juvenile onset

• C-Peptid levels below 1.0 ng/ml

• Previous major upper abdominal surgery

  --Pregnant or plans to become pregnant with in the next 12 months

• Current Malignancy

• Severe pulmonary, cardia, or renal disease

• Eating disorders such as bulimia or binge-eating

• Severe mental health disorders such as schizophrenia and bipolar disorder

• Obesity due to other metabolic disorders

• taking appetite suppressants

• currently abusing illicit drugs,alcohol or using tobacco products

• Unable to provide informed consent

• Unwillingness or unable to comply with study procedures

• any condition that deems them unsuitable for the study in the opinion of the investigators