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The medulloblastome is a tumour of the child relatively frequent usually sitting in the cerebellum and treated by surgery, radiotherapy and chemotherapy. After the treatment, these children present cognitive disorders and in particular disorders of the working memory associated with a fall with the school performances. By studying a troop of 32 children, we could show that the disorders of the working memory prevail during the handling of information presented visually and with verbal contents. However, the specific engagement of the cerebellum in the tasks of working memory according to the sensory method of presentation (visual or auditive) and the nature (verbal or not verbal) of information to treat vague remainder. Moreover, the anatomical attacks associated with these disorders remain ignored in these children. The best comprehension of the bases anatomo-functional calculuses which underlie their cognitive deficits is essential to develop new strategies of treatment and rehabilitation.
Objectives:
The functional study should make it possible to show the specifically committed networks according to the cognitive tasks. Among patients, the relative difficulty to carry out the tasks of working memory should be accompanied by a recruitment of the dorso-side cortex préfrontal, lower and parietal frontal cortex but also of the median frontal areas such as the additional driving surface, the former cingulum. Moreover, one deterioration of the engagement of the cérébello-cerebral network (left lower parietal cortex and cérébelleux cortex lower right) facilitating the execution of these tasks should be observed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| healthy volonteer children | paired for the sex and the age |
| |
| older children followed for a médulloblastome cérébelleux | children followed for a médulloblastome treaty by surgery, radiotherapy and chemotherapy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| IRMf Bold | Other | IRMf BOLD of the working memory |
|
Inclusion Criteria:
Exclusion Criteria:
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child Treaties for a médulloblastome after the 6 years age
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Isabelle I SCHIFF | Contact | 0476762635 | ISchiff@chu-grenoble.fr |
| Name | Affiliation | Role |
|---|---|---|
| Anne A PAGNIER, Doctor | University Hospital, Grenoble | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University hospital | Recruiting | Bordeaux | Bordeaux | 33076 | France |
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| Institut d'Hématologie et d'Oncologie Pédiatrique | Recruiting | Lyon | Lyon | 69008 | France |
|
| Hôpital Frédéric Joliot Orsay - Hôpital Necker | Recruiting | Paris | Paris | 75015 | France |
|
| Institut Curie | Recruiting | Paris | Paris | 75231 | France |
|
| University Hospital | Recruiting | Saint-Etienne | Saint Etienne | 42055 | France |
|
| Institut Gutave Roussy | Recruiting | Villejuif | Villejuif | 94805 | France |
|
| SMAEC | Recruiting | Villeurbanne | Villeurbanne | 69100 | France |
|
| UniversityHospitalGrenoble | Recruiting | Grenoble | 38043 | France |
|