Comparative Analysis of BioXtra on Xerostomia

Comparison Study of BioXtra Spray and Mouth Rinse in Patient With Radiation-induced Xerostomia

The present study compared the efficacy of BioXtra spray and mouth rinse in the relief of radiotherapy-induced xerostomia in patients referred to Cancer Institute, Tehran Imam Khomeini Hospital.

Xerostomia or dry mouth is an important complication of radiotherapy for head and neck regions producing serious discomfort for patients with a significant reduction in their quality of life. Symptomatic treatments for the disease include maintain oral hygiene and use of artificial saliva substitutes.

Due to limited studies on efficacy compounds BioXtra, present study compared the effects of spray and mouth rinse BioXtra in symptoms of xerostomia in patients under head and neck cancer radiotherapy .

Inclusion Criteria:

• complaint of xerostomia after head and neck radiotherapy
• patient must have given written informed consent

Exclusion Criteria:

• age under 18 years
• history of any treatment for cancer in the last 3 months
• recurrence of cancer and end stage of it
• diabetes mellitus
• sjogren syndrome or other medical causes of xerostomia
• drug therapy which might induce xerostomia
• refusal of cooperation or consent