Endothelial Function Study Before Cardiovascular Surgery

Endothelial Function Study Before Cardiovascular Surgery in COPD and/or SAS Patients

The aim of this clinical trial is to evaluate the effect of chronic obstructive pulmonary disease (COPD) and/or obstructive sleep apnea syndrome (OSAS) on the endothelial function, before cardiovascular surgery, compared to non COPD non OSAS patients undergoing also a cardiovascular surgery, by an observational physiological study.

An interim analysis will be performed when 100 patients will be included.

Secondary objectives of this clinical trial :

• To evaluate the effect of COPD and/or OSAS on the systemic inflammation, insulin-resistance and oxydative stress, in comparison with non COPD non OSAS patients.
• To evaluate the effect of COPD and/or OSAS on the inflammation and oxydative stress of the adipose tissue, in comparison with non COPD non OSAS patients.
• To validate the STOP-BANG questionnaire in patients undergoing a cardiovascular surgery

Inclusion Criteria:

• Men or women between 18 and 80 years old
• Patient with planned coronary artery bypass graft surgery
• Patient with planned peripheral vascular surgery
• Patient with aortic surgery

Exclusion Criteria:

• Patient with aortic or mitral valvular replacement
• Patient with emergency peripheral valvular surgery
• Patient with emergency coronary artery bypass graft surgery
• Patient with evolutive malignancy disease
• Pregnant or lactating women
• Patient with inadvisable bronchodilator (used for functional respiratory) exploration