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The aim of this clinical trial is to evaluate the effect of chronic obstructive pulmonary disease (COPD) and/or obstructive sleep apnea syndrome (OSAS) on the endothelial function, before cardiovascular surgery, compared to non COPD non OSAS patients undergoing also a cardiovascular surgery, by an observational physiological study.
An interim analysis will be performed when 100 patients will be included.
Secondary objectives of this clinical trial :
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| COPD+ OSAS- patients | Patients with chronic obstructive pulmonary disease (COPD) and without obstructive sleep apnea syndrome (OSAS), before planned cardiovascular surgery | ||
| COPD- OSAS+ patients | Patients with obstructive sleep apnea syndrome (OSAS) and without chronic obstructive pulmonary disease (COPD), before planned cardiovascular surgery | ||
| COPD+ OSAS+ patients | Patients with chronic obstructive pulmonary disease (COPD) and with obstructive sleep apnea syndrome (OSAS), with planned cardiovascular surgery | ||
| COPD- OSAS- patients | Patients without chronic obstructive pulmonary disease (COPD) and without obstructive sleep apnea syndrome (OSAS), before planned cardiovascular surgery |
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| Measure | Description | Time Frame |
|---|---|---|
| The primary endpoint is the percent of peripheral arterial tone (PAT) in COPD and/or OSAS patients compared to non COPD non OSAS patients. | one week before their cardiovascular surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Evaluation of the systemic inflammation, insulin-resistance and oxidative stress occurring during COPD and/or OSAS patients compared to non COPD non OSAS patients. | one week before their cardiovascular surgery | |
| Evaluation of adipose tissue inflammation and oxidative stress occurring during COPD and/or OSAS patients compared to non COPD non OSAS patients. |
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Inclusion Criteria:
Exclusion Criteria:
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Patients presenting with chronic obstructive pulmonary disease (COPD) and/or obstructive sleep apnea syndrome (OSAS) or control patients without these pathologies, before planned cardiovascular surgery.
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| Name | Affiliation | Role |
|---|---|---|
| Jean-Louis PEPIN, MD, PhD | University Hospital of Grenoble, France | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital of Angers | Angers | 49033 | France | |||
| Mutualist Hospital group |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 17765529 | Background | Fabbri LM, Rabe KF. From COPD to chronic systemic inflammatory syndrome? Lancet. 2007 Sep 1;370(9589):797-9. doi: 10.1016/S0140-6736(07)61383-X. No abstract available. |
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| ID | Term |
|---|---|
| D029424 | Pulmonary Disease, Chronic Obstructive |
| D020181 | Sleep Apnea, Obstructive |
| ID | Term |
|---|---|
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D002908 | Chronic Disease |
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Urinary, blood and adipose tissue samples will be collected for measurement of different parameters of inflammation and oxidative stress.
| one week before their cardiovascular surgery |
| Polysomnography | one week before their cardiovascular surgery |
| Functional respiratory exploration | one week before their cardiovascular surgery |
| Grenoble |
| 38000 |
| France |
| University Hospital of Grenoble | Grenoble | 38043 | France |
| D020969 |
| Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012891 | Sleep Apnea Syndromes |
| D001049 | Apnea |
| D012120 | Respiration Disorders |
| D020919 | Sleep Disorders, Intrinsic |
| D020920 | Dyssomnias |
| D012893 | Sleep Wake Disorders |
| D009422 | Nervous System Diseases |