The purpose of this study is to investigate features of radioligand [11C]AZ12807110 and how much AZD5213 displaces radioligand from histamine receptors when given together.

Inclusion Criteria:

• Healthy male and/or female volunteers between 20 to 45 years with suitable veins for cannulation or repeated venipuncture (pilot panel)
• Female must be of non-child bearing potential (pilot panel)
• BMI between 18 to 30 30 kg/m2
• Normal MRI scan
• Provision of signed, written and dated informed consent

Exclusion Criteria:

• History of any clinically significant disease or disorder
• History or presence of gastrointestinal, hepatic or renal disease
• Prolonged QTcF >450 ms or shortened QTcF <340 ms or family history of long QT syndrome
• History of severe allergy or hypersensitivity or ongoing allergy or hypersensitivity
• Healthy volunteer suffers from claustrophobia