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Albendazole is a main anti-helminth, however there is a lack of data regarding its efficacy in the school children population. The aim of this study is to evaluate the efficacy of the albendazole one versus two and three doses, in school children infected with intestinal helminth.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 dose, Albendazole , tablet | Active Comparator |
| |
| 2 doses, albendazole, tablet | Active Comparator | 1 tablet of 400 mg of albendazole per day for two consecutive days |
|
| 3 doses albendazole, 400mg, tablet | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| albendazole | Drug | 1 tablet of 400 mg of albendazole per day for three consecutive days |
|
| Measure | Description | Time Frame |
|---|---|---|
| parasite cleared and reduced up to 80% at day 42 | 42 days |
| Measure | Description | Time Frame |
|---|---|---|
| Prevalence of major gut bacteria | Change in the prevalence of major gut bacteria after antihelminth treatment. | 42 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medical research Unit of Lambaréné | Lambaréné | Moyen-Ogooué Province | 118 | Gabon |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24550339 | Derived | Adegnika AA, Zinsou JF, Issifou S, Ateba-Ngoa U, Kassa RF, Feugap EN, Honkpehedji YJ, Dejon Agobe JC, Kenguele HM, Massinga-Loembe M, Agnandji ST, Mordmuller B, Ramharter M, Yazdanbakhsh M, Kremsner PG, Lell B. Randomized, controlled, assessor-blind clinical trial to assess the efficacy of single- versus repeated-dose albendazole to treat ascaris lumbricoides, trichuris trichiura, and hookworm infection. Antimicrob Agents Chemother. 2014 May;58(5):2535-40. doi: 10.1128/AAC.01317-13. Epub 2014 Feb 18. |
| Label | URL |
|---|---|
| Medical Research Unit of the Albert Schweitzer Hospital | View source |
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| ID | Term |
|---|---|
| D007410 | Intestinal Diseases |
| D006373 | Helminthiasis |
| D006725 | Hookworm Infections |
| ID | Term |
|---|---|
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
| D010272 | Parasitic Diseases |
| D007239 | Infections |
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| ID | Term |
|---|---|
| D015766 | Albendazole |
| ID | Term |
|---|---|
| D002219 | Carbamates |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
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| albendazole | Drug | single 1 tablet of 400 mg of albendazole |
|
| albendazole | Drug | 1 tablet of 400 mg of albendazole per day for two consecutive days |
|
| D017206 |
| Strongylida Infections |
| D017190 | Secernentea Infections |
| D009349 | Nematode Infections |
| D001562 |
| Benzimidazoles |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |