A Long-term Safety Study of Fluticasone Furoate (FF)/GW642444 in Japanese Subjects With COPD

A Long-term Study to Evaluate the Safety and Tolerability of Fluticasone Furoate (FF)/GW642444 Inhalation Powder in Japanese Subjects With Chronic Obstructive Pulmonary Disease (COPD)

The primary purpose of the study is to evaluate the safety and tolerability of fluticasone furoate/GW642444 inhalation powder when administered once-daily for 52 weeks in Japanese patients with COPD.

Inclusion Criteria:

• Out patient at least 40 years of age
• Both genders; females childbearing potencial must be willing to use birth control method
• A diagnosis of COPD at Screening
• Subjects with a current or prior history of at least 10 pack-years of cigarett smoking at Screening
• Post-bronchodilator FEV1/FVC ratio of less than 70%
• Post-bronchodilator FEV1 of less than 80%

Exclusion Criteria:

• Current diagnosis of sthma
• Respiratory disorders other than COPD
• Upper or lower respiratory infection, or exacerbation of COPD within 4 weeka prior to Screening
• Concurrent other disease that would confound study participation or affect subject safety
• Allergies to study drugs, study drugs' excipients, medications related to study drugs
• Taking another investigational medication or medication prohibited for use during this study