fMRI Cholinergic Mechanisms in Schizophrenia

fMRI Cholinergic Mechanisms in Schizophrenia

This study aims to determine how clozapine treatment improves neuronal measures of sensory gating in subjects with schizophrenia.

This study will use functional magnetic resonance imaging (fMRI) to study patients treated with risperidone, a commonly used neuroleptic that does not improves sensory gating, to those treated with clozapine to determine which brain areas are involved in clozapine's normalization of sensory gating in schizophrenia.

Inclusion Criteria:

• Diagnosis of schizophrenia
• age 18-60 yrs

Exclusion Criteria:

• claustrophobia
• weight > 250 lbs
• metal in body other than dental fillings