Pilot Study of Maintenance Therapy With Intravenous AMANTADINE

Maintenance Therapy of Intravenous Amantadine in Patients With Idiopathic Parkinson Disease Who Are Not Optimally Treated With Anti Parkinson Medications

This is a pilot study for Maintenance Intravenous Treatment with AMANTADINE in patient with PARKINSON'S Disease who are not well balanced with medical treatment.

Inclusion Criteria:

• Patients with idiopathic Parkinson disease
• Age<80
• Patients with no motor improvement under optimal treatment with anti parkinson medications
• Patients with moderate to severe dyskinesias
• Patients with PD with side effects who can not tolerate anti parkinson medications

Exclusion Criteria:

• Age>80
• Patients with Parkinson syndromes, vascular parkinsonism or drug-induced parkinsonism
• Patients with PD who developed adverse reactions to oral amantadine
• Contraindication of amantadine treatment