Metformin to Prevent Metabolic Complications in Glucocorticoid Excess

Metformin to Prevent Metabolic Complications in Glucocorticoid Excess

The purpose of this study is to evaluate if a treatment with metformin compared to placebo reduces metabolic side-effects in patients with glucocorticoid treatment over three months time.

Inclusion Criteria:

• Glucocorticoid treatment for ≥ 3 months with a prednisone dose of ≥ 7.5mg/d or equivalent glucocorticoid

Exclusion Criteria:

• Refusal of informed consent
• Prior therapy with metformin during the last 6 month
• Preexisting diabetes
• Pregnancy or current malignancy
• Renal insufficiency with a creatinine clearance lower than 30ml/min