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Evaluation of the multiple dose pharmacokinetics of PF-3715455 in healthy volunteers
Healthy volunteer PK study
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PF-03715455 1.6mg BID | Active Comparator |
| |
| PF-03715455 4 mg BID | Active Comparator |
| |
| PF-03715455 10 mg BID | Active Comparator |
| |
| Placebo | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PF-03715455 | Drug | PF-03715455 1.6 mg BID |
| |
| PF-03715455 |
| Measure | Description | Time Frame |
|---|---|---|
| Pharmacokinetics of single and multiple inhaled doses of PF-03715455, as measured by plasma concentrations - Cmax, Tmax, AUCtau, t½, accumulation ratio (Rac, Rss, Rac,Cmax). | 17 days |
| Measure | Description | Time Frame |
|---|---|---|
| Safety and toleration as measured by adverse events, vital signs, 12 lead ECG, blood and urine safety tests and physical examination. | 28 Days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Pfizer CT.gov Call Center | Pfizer | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Pfizer Investigational Site | Singapore | 188770 | Singapore |
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| Label | URL |
|---|---|
| To obtain contact information for a study center near you, click here. | View source |
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| ID | Term |
|---|---|
| C569762 | N-(1-(3-chloro-4-hydroxyphenyl)-3-(1,1-dimethylethyl)-1H-pyrazol-5-yl)-N'-((2-((3-(2-((2-hydroxyethyl)thio)phenyl)-1,2,4-triazolo(4,3-a)pyridin-6-yl)thio)phenyl)methyl)-urea |
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| Drug |
PF-03715455 4mg BID |
|
| PF-03715455 | Drug | PF-03715455 10 mg BID |
|
| Placebo | Drug | Placebo |
|