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| ID | Type | Description | Link |
|---|---|---|---|
| NJFY7M12 |
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Cognitive disorders in patients underwent general anesthesia are discussed for decades, but whether there were precise relationship between general anesthesia and dysgnosia is yet to be guaranteed. Although controversial data reported from experimental studies in animals, the investigators still proposed that general anesthetics could impair the normally organized system of the central nervous system, which finally displayed a dysfunction of cognition after general anesthesia in a short- or long-term period. Therefore, different types of general anesthetics such as inhalational anesthetics and intravenous anesthetics, the investigators hypothesized, had a long-term influence on patients' cognitive ability.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Local anesthesia | No Intervention | Patients received local anesthesia without any intervention of general anesthetics | |
| Inhalational anesthesia | Active Comparator | Patients received sevoflurane anesthesia during general anesthesia |
|
| Intravenous anesthesia | Active Comparator | Patients received intravenous anesthetic (Propofol) during general anesthesia |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sevoflurane | Drug | 1-8% sevoflurane for maintaining the whole period of general anesthesia |
|
| Measure | Description | Time Frame |
|---|---|---|
| Cognitive ability | Cognitive ability will be assessed with digital lignature game, figure identificaiton, and recall memory | The 10th year since postoperation |
| Measure | Description | Time Frame |
|---|---|---|
| Cognitive ability | Cognitive ability will be assessed with digital lignature game, figure identificaiton, and recall memory | One hour before operation |
| Cognitive ability | Cognitive ability will be assessed with digital lignature game, figure identificaiton, and recall memory |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| FuZhou Wang, PhD MD | Contact | 86 25 84460777 | 3301 | zfwang50@gmail.com |
| XiaoFeng Shen, MPH, MD | Contact | 86 25 84460777 | 3303 | sxf0418@njmu.edu.cn |
| Name | Affiliation | Role |
|---|---|---|
| FuZhou Wang, PhD MD | Nanjing Medical University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nanjing Maternity and Child Health Care Hospital | Recruiting | Nanjing | Jiangsu | 210004 | China |
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| ID | Term |
|---|---|
| D003693 | Delirium |
| D003704 | Dementia |
| D060825 | Cognitive Dysfunction |
| ID | Term |
|---|---|
| D003221 | Confusion |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D000077149 | Sevoflurane |
| D015742 | Propofol |
| ID | Term |
|---|---|
| D008738 | Methyl Ethers |
| D004987 | Ethers |
| D009930 | Organic Chemicals |
| D006845 | Hydrocarbons, Fluorinated |
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| Propofol | Drug | 1-4 mg/kg/h of propofol during the whole period of general anesthesia |
|
|
| Immediately after operation (0 day) |
| Cognitive ability | Cognitive ability will be assessed with digital lignature game, figure identificaiton, and recall memory | One month after operation |
| Cognitive ability | Cognitive ability will be assessed with digital lignature game, figure identificaiton, and recall memory | Six month after operation |
| Cognitive ability | Cognitive ability will be assessed with digital lignature game, figure identificaiton, and recall memory | One year after operation |
| Cognitive ability | Cognitive ability will be assessed with digital lignature game, figure identificaiton, and recall memory | Once a year from the 1st year after operation up to 9th year |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D003072 | Cognition Disorders |
| D006846 |
| Hydrocarbons, Halogenated |
| D006838 | Hydrocarbons |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |