A Randomized, Double-blind, Multicenter Phase 3 Study of Irinotecan, Folinic Acid, and 5-Fluorouracil (FOLFIRI) Plus Ramucirumab or Placebo in Patients With Metastatic Colorectal Carcinoma Progressive During or Following First-Line Combination Therapy With Bevacizumab, Oxaliplatin, and a Fluoropyrimidine
A Randomized, Double-blind, Multicenter Phase 3 Study of Irinotecan, Folinic Acid, and 5-Fluorouracil (FOLFIRI) Plus Ramucirumab or Placebo in Patients With Metastatic Colorectal Carcinoma Progressive During or Following First-Line Combination Therapy With Bevacizumab, Oxaliplatin, and a Fluoropyrimidine
The purpose of this study is to compare overall survival in participants with metastatic colorectal cancer treated with either ramucirumab and FOLFIRI or placebo and FOLFIRI.
Inclusion Criteria:
Exclusion Criteria:
Sedona, Arizona 86336, United States
Tucson, Arizona 85715, United States
Fayetteville, Arkansas 72703, United States
Little Rock, Arkansas 72205, United States
Duarte, California 91010, United States
Escondido, California 92025, United States
Fresno, California 93720, United States
Greenbrae, California 94904, United States
La Jolla, California 92093, United States
Rancho Cucamonga, California 91730, United States
San Diego, California 92108, United States
Denver, Colorado 80218, United States
Waterbury, Connecticut 06708, United States
Boynton Beach, Florida 33426, United States
Fort Lauderdale, Florida 33308, United States
Fort Myers, Florida 33916, United States
Miami, Florida 33176, United States
Ocala, Florida 34471, United States
Port Saint Lucie, Florida 34952, United States
St. Petersburg, Florida 33705, United States
Titusville, Florida 32796, United States
Athens, Georgia 30607, United States
Augusta, Georgia 30901, United States
Macon, Georgia 31201, United States
Marietta, Georgia 30060, United States
Rome, Georgia 30165, United States
Thomasville, Georgia 31792, United States
Honolulu, Hawaii 96819, United States
Harvey, Illinois 60426, United States
Peoria, Illinois 61615, United States
Warrenville, Illinois 60555, United States
Goshen, Indiana 46526, United States
Indianapolis, Indiana 46237, United States
Muncie, Indiana 47303, United States
Bethesda, Maryland 20817, United States
Minneapolis, Minnesota 55404, United States
Columbia, Missouri 65201, United States
St Louis, Missouri 63110, United States
Billings, Montana 59101, United States
Las Vegas, Nevada 89169, United States
Cherry Hill, New Jersey 08003, United States
Hackensack, New Jersey 07601, United States
Morristown, New Jersey 07962, United States
Albuquerque, New Mexico 87109, United States
Hudson, New York 12534, United States
Jamaica, New York 11432, United States
New York, New York 10029, United States
The Bronx, New York 10467, United States
Raleigh, North Carolina 27607, United States
Cincinnati, Ohio 45242, United States
Columbus, Ohio 43219, United States
Tulsa, Oklahoma 74136, United States
Bend, Oregon 97701, United States
Portland, Oregon 97227, United States
Kingston, Pennsylvania 18704, United States
Philadelphia, Pennsylvania 19106, United States
Willow Grove, Pennsylvania 19090, United States
Columbia, South Carolina 29210, United States
Memphis, Tennessee 38138, United States
Nashville, Tennessee 37203, United States
Abilene, Texas 79606, United States
Arlington, Texas 76014, United States
Beaumont, Texas 77702, United States
Bedford, Texas 76022, United States
Dallas, Texas 75246, United States
Denton, Texas 76210, United States
Flower Mound, Texas 75028, United States
Fort Worth, Texas 76104, United States
Garland, Texas 75042, United States
McAllen, Texas 78503, United States
Odessa, Texas 79761, United States
Paris, Texas 75460, United States
Round Rock, Texas 78665, United States
San Antonio, Texas 78229, United States
Sherman, Texas 75090, United States
Sugar Land, Texas 77479, United States
Temple, Texas 76508, United States
The Woodlands, Texas 77380, United States
Tyler, Texas 75702, United States
Waco, Texas 76712, United States
Webster, Texas 77598, United States
Wichita Falls, Texas 76310, United States
Ogden, Utah 84403, United States
Salt Lake City, Utah 84106, United States
Fairfax, Virginia 22031, United States
Newport News, Virginia 23606, United States
Richmond, Virginia 23230, United States
Winchester, Virginia 22601, United States
Kennewick, Washington 99336, United States
Seattle, Washington 98109, United States
Spokane Valley, Washington 99216, United States
Milwaukee, Wisconsin 53226, United States
Buenos Aires, B8000FJI, Argentina
Caba, C1180AAX, Argentina
Rosario, 2000, Argentina
Santa Fe, 3000, Argentina
Tucumain, 4000, Argentina
Viedma, 8500, Argentina
Liverpool, New South Wales 2170, Australia
Randwick, New South Wales 2031, Australia
St Leonards, New South Wales 2065, Australia
Wodonga, New South Wales 3690, Australia
Wollongong, New South Wales 2500, Australia
Woolloongabba, Queensland 4102, Australia
Bedford Park, South Australia 5042, Australia
Elizabeth Vale, South Australia 5112, Australia
Innsbruck, 6020, Austria
Krems, 3500, Austria
Vienna, A1090, Austria
Bonheiden, 2820, Belgium
Brussels, 1070, Belgium
Charleroi, 6000, Belgium
Edegem, 2650, Belgium
Haine-St.- Paul, 7100, Belgium
Leuven, 3000, Belgium
Liège, 4000, Belgium
Ijuí, 98700 000, Brazil
Itajaí, 88301-220, Brazil
Rio de Janeiro, 20231-050, Brazil
Salvador, 41823-010, Brazil
São José do Rio Preto, 15025-100, Brazil
São Paulo, 01308-050, Brazil
Brno, 656 53, Czechia
Pardubice, 532 03, Czechia
Prague, 150 06, Czechia
Copenhagen, 2100, Denmark
Odense, 5000, Denmark
Helsinki, 00029 HUS, Finland
Tampere, 33521, Finland
Bordeaux, 33076, France
La Chaussée-Saint-Victor, 41260, France
Le Mans, 72000, France
Nantes, 44202, France
Paris, 75015, France
Poitiers, 86021, France
Strasbourg, 67000, France
Augsburg, 86150, Germany
Balingen, 72336, Germany
Bamberg, 96049, Germany
Dresden, 01307, Germany
Frankfurt, 60488, Germany
Halle, 06120, Germany
Hamburg, 20249, Germany
Lübeck, 23562, Germany
Mönchengladbach, 41063, Germany
Munich, 81925, Germany
Weiden, 92637, Germany
Athens, 10676, Greece
Chania, 73300, Greece
Ioannina, 45500, Greece
Budapest, 1115, Hungary
Kecskemét, 6000, Hungary
Bangalore, 560027, India
Kochi, 628040, India
Kolkata, 700053, India
New Delhi, 110 060, India
Trivandrum, 695 011, India
Beersheba, 84101, Israel
Haifa, 31096, Israel
Tel Aviv, 64239, Israel
Tel Litwinsky, 52621, Israel
Genova, 16132, Italy
Livorno, 57124, Italy
Padova, 35128, Italy
Province of Macerata, 62100, Italy
Reggio Emilia, 42100, Italy
Rome, 00168, Italy
Aichi, 464, Japan
Chiba, 277 8577, Japan
Ehime, 790-0007, Japan
Fukuoka, 811-1395, Japan
Gifu, 501-1194, Japan
Hokkaido, 060-8638, Japan
Hyōgo, 650-0046, Japan
Kanagawa, 216-8511, Japan
Kochi, 781-8555, Japan
Osaka, 569-8686, Japan
Saitama, 362-0806, Japan
Shizuoka, 411-8777, Japan
Tochigi, 329-0498, Japan
Tokyo, 104-0045, Japan
Breda, 4819 EV, Netherlands
Deventer, 7416 SE, Netherlands
Eindhoven, 5623 EJ, Netherlands
Groningen, 9728 NT, Netherlands
Sittard - Geleen, 6162 BG, Netherlands
Coimbra, 3000-075, Portugal
Porto, 4200-072, Portugal
Bayamón, 00959, Puerto Rico
Bucharest, 022328, Romania
Cluj-Napoca, 400015, Romania
Iași, 700106, Romania
Oradea, 410469, Romania
Ljubljana, 1001, Slovenia
Anyang, 431-070, South Korea
Goyang-si, 411-764, South Korea
Incheon, 405-760, South Korea
Seoul, 134-791, South Korea
Suwon, 442-721, South Korea
Barcelona, 08035, Spain
Madrid, 28097, Spain
Oviedo, 33006, Spain
Pamplona, 31008, Spain
Sabadell, 08208, Spain
Seville, 41013, Spain
Valencia, 46014, Spain
Stockholm, 17176, Sweden
Uppsala, 75185, Sweden
Kaohsiung City, 807, Taiwan
Kuei Shan Hsiang, 33305, Taiwan
Taichung, 40705, Taiwan
Tainan, 70403, Taiwan