Fabry and Stroke Epidemiological Protocol (FASEP): Risk Factors In Ischemic Stroke Patients With Fabry Disease

FASEP Fabry and Stroke Epidemiological Protocol RISK FACTORS IN ISCHEMIC STROKE PATIENTS WITH FABRY DISEASE AN INTERNATIONAL, MULTICENTER, EPIDEMIOLOGICAL PROTOCOL

More than one million people in Europe suffer from a stroke every day. Normally older people have a stroke, but also a significant number of younger people between 18 and 55 years. Usually, these can only be explained for a minority by the classical risk factors such as diabetes, overweight and high blood pressure. New studies indicate that in about 1 - 2 % of the younger stroke patients the etiology can be an undiagnosed genetic disease, e.g. Fabry disease. Fabry disease is a lysosomal storage disorder known to cause vasculopathy. The purpose of this study is to determine in a large number of young stroke patients, how many strokes were caused by Fabry disease and what risk factors might be able to predict this disease.

Inclusion Criteria:

• Adult patients (18 - 60 years of age) with an acute ischemic cerebrovascular event either acute ischemic stroke or transient ischemic attack within 10 days
• Diagnosis of the cerebrovascular event (CVE) by a stroke experienced physician
• Diagnostic procedures for CVE according to the local guidelines and recommendations
• Written informed consent from patient or legal representative according to local regulations

Exclusion Criteria:

• Patients being younger than 18 years or older than 60 years of age.
• Acute ischemic stroke or transient ischemic attack longer than 10 days before enrollment into the study
• CVE associated with intracranial hemorrhage as evidenced by cerebral CT scan
• Any uncertainty in the diagnosis
• No written informed consent from the patient or legal representative