Alcohol Interaction Study

A Study to Investigate the Psychomotor and Cognitive Effects of Alcohol When Co-administered With GSK1144814 or Matching Placebo in Healthy Subjects.

The purpose of this study is understand the effects of GSK114814 and alcohol in healthy volunteers when taken together.

The primary objective of this study is to investigate the CNS effects of co-administration of GSK1144814 with alcohol. Healthy volunteers who meet the eligibility criteria will be randomized to receive GSK1144814 or placebo with alcohol.

Inclusion Criteria:

• Healthy male and female
• Body weight 50 kg or higher and BMI within the range 19 - 29.9 kg/m2
• Willing to use appropriate contraception methods

Exclusion Criteria:

• Positive HIV, Hepatitis B surface antigen or Hepatitis C antibody result
• Any serious medical disorder or condition
• Any history of an endocrine disorder.
• Any clinically significant laboratory abnormality.
• History of psychiatric illness.
• Any history of suicidal attempts or behavior.
• Positive urine drug screen or positive blood alcohol
• Pregnant, nursing or potential to have a child
• Past history of alcohol dependence or abuse.
• History of increased sensitivity to the effects of alcohol or violent behaviour/aggression when intoxicated.
• smokers