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| Name | Class |
|---|---|
| University of Navarrra Hospital (Clinica Universitaria) | OTHER |
| Fundación para la Investigación del Hospital Clínico de Valencia | OTHER |
| Puerta de Hierro University Hospital | OTHER |
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The aim of the present study is to compare the response to cardiac resynchronization therapy (CRT) in patients with chronic advanced heart failure and permanent atrial fibrillation (AF) depending on atrio ventricular junction (AVJ) is ablated or not.
Cardiac resynchronization therapy (CRT) improves the functional capacity and the quality of life and reduces the mortality of patients with dilated cardiomyopathy, low ejection fraction and wide QRS.
Only 2% of patients included in CRT randomized trials were in AF.
To obtain a good response to CRT, percentage >90% of ventricular pacing must be obtained.
Based on observational studies, current guidelines of CRT recommend the atrio ventricular junction (AVJ) ablation in those patients with permanent atrial fibrillation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Atrioventricular junction ablation | Experimental | Atrioventricular junction ablation by using radiofrequency energy. |
|
| Drug control of ventricular rate | Active Comparator | Drug control of ventricular rate. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Atrio ventricular junction ablation with radio-frequency | Procedure | Atrioventricular junction ablation by using radiofrequency energy. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Left ventricular reverse remodelling in cardiac resynchronization therapy and atrial fibrillation. | Comparison of echocardiographic responders in patients with permanent atrial fibrillation submitted to cardiac resynchronization therapy depending on whether the atrio-ventricular junction is ablated or not. Echocardiographic response was defined as left ventricular end-systolic volume reduction >10%. | 1-year follow-up |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical response to Cardiac resynchronization therapy. | Comparison of clinical response in patients with permanent atrial fibrillation submitted to cardiac resynchronization therapy, depending on whether the atrio-ventricular junction has been ablated or not. Clinical response is defined as not death/heart transplantation and improvement of the distance walked in the 6-minute walking test >10%. |
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Inclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jose M Tolosana, M.D. | Hospital Clinic, University of Barcelona | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital Clinic de Barcelona | Barcelona | Barcelona | 08036 | Spain |
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| ID | Term |
|---|---|
| D002311 | Cardiomyopathy, Dilated |
| D001281 | Atrial Fibrillation |
| ID | Term |
|---|---|
| D006332 | Cardiomegaly |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D009202 | Cardiomyopathies |
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| ID | Term |
|---|---|
| D000319 | Adrenergic beta-Antagonists |
| ID | Term |
|---|---|
| D018674 | Adrenergic Antagonists |
| D018663 | Adrenergic Agents |
| D018377 | Neurotransmitter Agents |
| D045504 | Molecular Mechanisms of Pharmacological Action |
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| Hospital Universitario Ramon y Cajal | OTHER |
| Hospital Universitario La Fe | OTHER |
| Hospital Universitario La Paz | OTHER |
| Fundación Pública Andaluza para la gestión de la Investigación en Sevilla | OTHER |
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| Beta blocker/digoxine/amiodarone | Drug | Ventricular rate control by using drug treatment. |
|
|
| 1-year follow-up |
| D000083083 |
| Laminopathies |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D001145 | Arrhythmias, Cardiac |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
| D045505 | Physiological Effects of Drugs |