Comparison of Proton Pump Inhibitor and H2 Receptor Blocker on Prevention of Bleeding From Iatrogenic Ulcer After Endoscopic Submucosal Dissection for Gastric Neoplasms: A Prospective Randomized Controlled Trial

Comparison of Proton Pump Inhibitor and H2 Receptor Blocker on Prevention of Bleeding From Iatrogenic Ulcer After Endoscopic Submucosal Dissection for Gastric Neoplasms: A Prospective Randomized Controlled Trial

after endoscopic submucosal dissection(ESD) of early gastric cancer, conventional proton pump(PPI) inhibitors and H2 receptor antagonists have a controversial effect on preventing bleeding from artificial ulcers. the aim of this study was to investigate whether a stronger acid suppression (high dose PPI) more effectively prevents bleeding after ESD

Inclusion Criteria:

• the patients who agreed informed consent
• gastric adenoma or early gastric cancer which is eligible for conventional ESD indication

Exclusion Criteria:

• recent drug history of PPI, H2 rector antagonist, bismuth and antibiotics within 4 weeks
• recent drug history of anticoagulant or antiplatelet agent within 7 days
• s/p subtotal gastrectomy
• recurred gastric adenoma or cancer
• pregnant or breast feeding patients