This is a pilot study to evaluate the difference between the protein expression between hepatocellular carcinoma and tumor with vessel invasion in Asian patients with hepatocellular carcinoma.

Inclusion Criteria:

Arm A: Hepatocellular carcinoma with vessel invasion:

• hepatocellular carcionoma, pathologic diagnosed.
• image documented vessel invasion, including portal vein thrombosis
• eligible for surgical intervension.

Arm B: hepatocellular carcinoma without vessel invasion:

• hepatocellular carcinoma, pathologic diagnosed or clinical diagnosed according to EASL criteria.
• no vessel invasion on image.

Arm C: Healthy hepatitis carrier:

• patients age >18 years old with hepatitis B or C
• normal liver function.