Probiotics and Endotoxemia

Probiotics and Endotoxemia in Humans

The purpose of this study is to determine whether probiotic treatment of overweight volunteers consuming high fat diet is able to reduce plasma lipopolysaccharide concentration.

Inclusion Criteria:

• Body mass index ≥ 27 kg/m2; above 18 years of age
• Used to eat high fat diet (more than 40% of total energy intake)

Exclusion Criteria:

• Treated cardiovascular risk factors, treated hypertension, treated dyslipidemia, treated diabetes; Known diabetes, hypertension, dyslipidemia
• Severe illnesses
• Artificial heart valve
• Immunosuppression
• Regular consumption of probiotics
• History of bariatric surgery
• Consumption or wish to consume Orlistat
• Participation in other research
• Pregnancy or wishing/trying to get pregnant
• Inability to follow protocol.