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Since nicardipine is known to protect kidney function, nicardipine infusion will result in better renal parameters measured in this study.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| nicardipine | Experimental |
| |
| remifentanil | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Nicardipine | Drug |
| ||
| remifentanil |
| Measure | Description | Time Frame |
|---|---|---|
| Creatinine Clearance | Hypotensive anesthesia means that we maintain the mean blood pressure between 55 & 65 mmHg during surgery to decrease the blood loss. The specific time point is exactly 2hr after we star to lower the blood pressure. | 2hr after the start of hypotensive anesthesia |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Ji Young Kim | Severance hospital, YUHS | Principal Investigator |
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| ID | Term |
|---|---|
| D009529 | Nicardipine |
| D000077208 | Remifentanil |
| ID | Term |
|---|---|
| D004095 | Dihydropyridines |
| D011725 | Pyridines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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0.1-0.5 ugkg/min during hypotensive anesthesia |
|
|
| D011422 |
| Propionates |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
| D010880 | Piperidines |