Omega 3 Fatty Acid Efficiency for Prevention of Atrial Fibrillation After Coronary Artery Bypass Grafting

Randomized Trial of Fish Oil Infusion to Prevent Atrial Fibrillation After Cardiac Surgery

The purpose of this study is to evaluate efficacy of Polyunsaturated Fatty Acid for the prevention of Atrial Fibrillation and anti-inflammatory effects in patients after CABG surgery

Inclusion Criteria:

• Elective CABG surgery.
• Signed, documented informed consent prior to admission to the study.

Exclusion Criteria:

• Unstable angina, requiring intervention or CABG <24 hrs after screening.
• Decompensated congestive heart failure.
• Chronic, persistent, paroxysmal atrial fibrillation.
• Uncorrected significant valvular heart disease
• Known hypersensitivity to the study drug
• Left ventricular dysfunction (ejection fraction <35%)
• Use of anti-arrhythmic drugs other than beta blockers
• Non-cardiac illness with a life expectancy of less than 1 year
• Bleeding diathesis or history of coagulopathy
• Significant renal and liver insufficiency
• Significant thyroid, pulmonary disease
• Uncontrolled diabetes mellitus
• Patients on anti-arrhythmic drugs
• Patients with pacemaker
• Patients unable to provide/sign informed consent.
• Patients currently taking marine based omega-three fish oil supplements.
• Disturbances in lipid metabolism, serum triglyceride value >3 mmol/l