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| Name | Class |
|---|---|
| University of Copenhagen | OTHER |
| European Foundation for the Study of Diabetes | OTHER |
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The incretin effect in patients with type two diabetes is reduced. The investigators have previously shown that it is possible to induce a defect in the incretin effect in healthy individuals. The purpose of this study is to evaluate the insulinotropic affect of the incretin hormones in healthy individuals before and after a deterioration of the glucose homeostasis.
The incretin effect in patients with type two diabetes is reduced. The investigators have previously shown that it is possible to induce a defect in the incretin effect in healthy individuals. The purpose of this study is to evaluate the insulinotropic affect of the incretin hormones in healthy individuals before and after a deterioration of the glucose homeostasis. The evaluation is done by infusing GIP, GLP-1 or saline during hyperglycemic clamps.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| No intervention | Experimental | Each participant is examined during a normal, active lifestyle, without any intervention: The examinations include an OGTT, a glucagon test, three hyperglycemic clamps with infusion of a)GLP-1; b)GIP; c)Nacl |
|
| Intervention | Experimental | Each participant is examined during a 12 days intervention.The examinations include an OGTT, a glucagon test, three hyperglycemic clamps with infusion of a)GLP-1; b)GIP; c)Nacl |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Steroid hormone | Behavioral | Steroid hormone: 37,5 mg of prednisolone; High energy diet: 130 % of recommended daily energy intake; Relative physical inactivity: no exercise and at least 8 hours of rest/day |
| Measure | Description | Time Frame |
|---|---|---|
| Insulinotropic effect of incretin hormones | Measurements of the insulinotropic effect of incretin hormones before and after 12 days intervention with steroid treatment, high calorie diet and relative physical inactivity | 12 days |
| Measure | Description | Time Frame |
|---|---|---|
| Plasma concentration of glucagon | Measurements of plasma concentration of glucagon before and after 12 days intervention with steroid treatment, high calorie diet and relative physical inactivity | 12 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Katrine B Hansen, MD | Glostrup University Hospital | Principal Investigator |
| Filip K Knop, MD,PhD | Gentofte University Hospital | Study Chair |
| Tina Vilsbøll, MD,DmSc | Gentofte University Hospital | Study Chair |
| Jens J Holst, MD, DmSc | University of Copenhagen | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Clinical Physiology | Glostrup Municipality | DK-2600 | Denmark |
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| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| D057185 | Sedentary Behavior |
| ID | Term |
|---|---|
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D011239 | Prednisolone |
| ID | Term |
|---|---|
| D011246 | Pregnadienetriols |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
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| No intervention | Other |
|
| D001519 | Behavior |
| D000072473 |
| Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |