This is a First-In-Man study designed to examine the safety, tolerability, pharmacokinetics and functional activity of ADC3680B after single and multiple doses in healthy male volunteers.

Inclusion Criteria:

• Healthy male subjects between the ages of 18 and 55 years
• Body Mass Index (BMI) of 18 to 30 kg/m2
• Signed and dated written informed consent prior to admission into the study
• Willing and able to comply with the requirements of the protocol and available to complete the study

Exclusion Criteria:

• Evidence of history of any clinically significant medical disorder
• History of severe allergy/hypersensitivity or ongoing allergy/hypersensitivity