A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ADC3680B in Healthy Volunteers

A Double-Blind Randomized, Placebo-Controlled, Dose Escalating Study to Assess The Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple Doses of ADC3680B Administered Orally to Healthy Volunteers and to Investigate Food Effects on Pharmacokinetics After Single Oral Doses of ADC3680B

This is a First-In-Man study designed to examine the safety, tolerability, pharmacokinetics and functional activity of ADC3680B after single and multiple doses in healthy male volunteers.

Inclusion Criteria:

• Healthy male subjects between the ages of 18 and 55 years
• Body Mass Index (BMI) of 18 to 30 kg/m2
• Signed and dated written informed consent prior to admission into the study
• Willing and able to comply with the requirements of the protocol and available to complete the study

Exclusion Criteria:

• Evidence of history of any clinically significant medical disorder
• History of severe allergy/hypersensitivity or ongoing allergy/hypersensitivity