Treatment of Apathy in Alzheimer's Disease With Modafinil

Treatment of Apathy in Alzheimer's Disease With Modafinil

This study examined the effects of modafinil on apathetic symptomatology, performance of activities of daily living (ADLs) and caregiver burden in individuals with Alzheimer's disease (AD).

Inclusion Criteria:

• diagnosis of mild to moderate stage Probable Alzheimer's disease
• on a stable dose of a cholinesterase inhibitor medication for at least 30 days
• clinically elevated levels of apathy as measured by the Frontal Systems Behavior Scale

Exclusion Criteria:

• diagnosis of Major Depression
• focal brain lesion on neuroimaging
• history of significant substance abuse
• history of significant head trauma with loss if consciousness >10 minutes